Highlights•Osteoarthritis (OA) is a common and debilitating disease with no effective
treatments.•Articular chondrocyte behavior and matrix maintenance are major targets.•The …

Highlights•Different OA etiologies present a challenge for developing a single targeted
therapy.•Common mechanisms occur in inflammatory, mechanical, and oxidative stress in …

Osteoarthritis (OA) is associated with cartilage degeneration and an accompanying
inflammatory syndrome of the synovium in addition to alteration of the subchondral bone …

Osteoarthritis (OA) is the most prevalent joint disease in older people and is characterized
by the progressive destruction of articular cartilage, synovial inflammation, changes in …

Current advances in therapies for osteoarthritis : Current Opinion in Rheumatology Current
advances in therapies for osteoarthritis : Current Opinion in Rheumatology Log in or Register …

OBJECTIVE: The purpose of this article is to review the current status of drug development
as it relates to both molecular targets and clinical trials for osteoarthritis (OA). METHODS: A …

The rising prevalence of osteoarthritis (OA) in the general population has necessitated the
development of novel treatment options. It is critical to recognize the joint as a separate …

[Frontiers in Bioscience 4, d762-771, October 15, 1999] 762 FUTURE DIRECTIONS FOR
RESEARCH AND TREATMENT OF OSTEOARTHRITIS Charl Page 1 [Frontiers in Bioscience 4 …

Biological therapy is a thriving area of research and development, and is well established for
chronic forms of rheumatoid arthritis (RA) and ankylosing spondylitis (AS). However, there is …

The prevalence of osteoarthritis (OA) and the burden associated with the disease are
steadily increasing worldwide, representing a major public health challenge for the coming …