Adenosine A2A Receptor Antagonists Affects NMDA Glutamate Receptor Function. Potential to Address Neurodegeneration in Alzheimer's Disease
R Franco, R Rivas-Santisteban, M Casanovas, A Lillo… - Cells, 2020 - mdpi.com
(1) Background. N-methyl d-aspartate (NMDA) ionotropic glutamate receptor (NMDAR),
which is one of the main targets to combat Alzheimer's disease (AD), is expressed in both …
which is one of the main targets to combat Alzheimer's disease (AD), is expressed in both …
Methamphetamine-induced TNF-α gene expression and activation of AP-1 in discrete regions of mouse brain: potential role of reactive oxygen intermediates and lipid …
Cellular and molecular mechanisms of methamphetamine (METH)-induced neurotoxicity
may involve alterations of cellular redox status and induction of inflammatory genes. To …
may involve alterations of cellular redox status and induction of inflammatory genes. To …
Influence of N‐methyl‐D‐aspartate receptors on ouabain activation of nuclear factor‐κB in the rat hippocampus
EM Kawamoto, LS Lima, CD Munhoz… - Journal of …, 2012 - Wiley Online Library
It has been shown that ouabain (OUA) can activate the Na, K‐ATPase complex and mediate
intracellular signaling in the central nervous system (CNS). Inflammatory stimulus increases …
intracellular signaling in the central nervous system (CNS). Inflammatory stimulus increases …
Enhanced dopamine-dependent hippocampal plasticity after single MK-801 application
JC Bartsch, P Fidzinski, JHJ Huck, H Hörtnagl… - …, 2015 - nature.com
Dopaminergic hyperfunction and N-methyl-D-aspartate receptor (NMDAR) hypofunction
have both been implicated in psychosis. Dopamine-releasing drugs and NMDAR …
have both been implicated in psychosis. Dopamine-releasing drugs and NMDAR …
Adenosine A2A receptor blockade differentially influences excitotoxic mechanisms at pre‐ and postsynaptic sites in the rat striatum
MT Tebano, A Pintor, C Frank… - Journal of …, 2004 - Wiley Online Library
Adenosine A2A receptor antagonists are being regarded as potential neuroprotective drugs,
although the mechanisms underlying their effects need to be better studied. The aim of this …
although the mechanisms underlying their effects need to be better studied. The aim of this …
Adenosine A1 receptor activation modulates N-methyl-d-aspartate (NMDA) preconditioning phenotype in the brain
LC Constantino, FA Pamplona, FC Matheus… - Behavioural Brain …, 2015 - Elsevier
Abstract N-methyl-d-aspartate (NMDA) preconditioning is induced by subtoxic doses of
NMDA and it promotes a transient state of resistance against subsequent lethal insults …
NMDA and it promotes a transient state of resistance against subsequent lethal insults …
Gene expression analysis indicates reduced memory and cognitive functions in the hippocampus and increase in synaptic reorganization in the frontal cortex 3 weeks …
P Petschner, V Tamasi, C Adori, E Kirilly, RD Ando… - BMC genomics, 2018 - Springer
Abstract Background 3, 4-methylenedioxymethamphetamine (MDMA,“ecstasy”) is a widely
used entactogenic drug known to impair cognitive functions on the long-run. Both …
used entactogenic drug known to impair cognitive functions on the long-run. Both …
Assessment of the role of α-methylapinine in the neurotoxicity of MDMA
TD Steele, WK Brewster, MP Johnson… - Pharmacology …, 1991 - Elsevier
To assess the potential involvement of metabolism of 3, 4-
methylenedioxymethamphetamine (MDMA) to the catechol α-methylepinine in producing …
methylenedioxymethamphetamine (MDMA) to the catechol α-methylepinine in producing …
[HTML][HTML] Neuronal activation of nucleus accumbens by local methamphetamine administration induces cognitive impairment through microglial inflammation in mice
Y Kusui, N Izuo, R Tokuhara, T Asano, A Nitta - Journal of Pharmacological …, 2024 - Elsevier
More than half of methamphetamine (METH) users present with cognitive impairment,
making it difficult for them to reintegrate into society. However, the mechanisms of METH …
making it difficult for them to reintegrate into society. However, the mechanisms of METH …
MK-801 prevents cognitive and behavioral deficits produced by NMDA receptor overstimulation in the rat hippocampus
BC Rogers, HA Tilson - Toxicology and applied pharmacology, 1989 - Elsevier
The overstimulation of receptors for l-glutamate, particularly those of the N-methyl-d-
aspartate (NMDA) type, has been suggested to play a role in mediating damage in a variety …
aspartate (NMDA) type, has been suggested to play a role in mediating damage in a variety …