[HTML][HTML] The endocannabinoid anandamide protects neurons during CNS inflammation by induction of MKP-1 in microglial cells

E Eljaschewitsch, A Witting, C Mawrin, T Lee… - Neuron, 2006 - cell.com
Endocannabinoids are released after brain injury and believed to attenuate neuronal
damage by binding to CB 1 receptors and protecting against excitotoxicity. Such excitotoxic …

[HTML][HTML] Anxiolytic effect of exogenous ketone supplementation is abolished by adenosine A1 receptor inhibition in Wistar Albino Glaxo/Rijswijk rats

Z Kovács, DP D'Agostino, C Ari - Frontiers in Behavioral …, 2018 - frontiersin.org
Anxiety disorders are one of the most common mental health problems worldwide, but the
exact pathophysiology remains largely unknown. It has been demonstrated previously that …

Progression and persistence of neurotoxicity induced by MDMA in dopaminergic regions of the mouse brain and association with noradrenergic, GABAergic, and …

G Costa, M Morelli, N Simola - Neurotoxicity research, 2017 - Springer
Abstract The amphetamine-related drug 3, 4methylenedioxymethamphetamine (MDMA) is
known to induce neurotoxic damage in dopaminergic regions of the mouse brain. In order to …

Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by β-amyloid peptides via p38 mitogen-activated protein kinase pathway

PM Canas, LO Porciúncula, GMA Cunha… - Journal of …, 2009 - Soc Neuroscience
Alzheimer's disease (AD) is characterized by memory impairment, neurochemically by
accumulation of β-amyloid peptide (namely Aβ1-42) and morphologically by an initial loss of …

Adenosine A2A receptor agonist polydeoxyribonucleotide ameliorates short-term memory impairment by suppressing cerebral ischemia-induced inflammation via …

IG Ko, JJ Jin, L Hwang, SH Kim, CJ Kim, JW Jeon… - PLoS …, 2021 - journals.plos.org
Cerebral ischemia causes tissue death owing to occlusion of the cerebral blood vessels,
and cerebral ischemia activates mitogen-activated protein kinase (MAPK) and induces …

Adenosine A2A receptor inactivation alleviates early-onset cognitive dysfunction after traumatic brain injury involving an inhibition of tau hyperphosphorylation

ZA Zhao, Y Zhao, YL Ning, N Yang, Y Peng, P Li… - Translational …, 2017 - nature.com
Tau is a microtubule-associated protein, and the oligomeric and hyperphosphorylated forms
of tau are increased significantly after neurotrauma and considered important factors in …

Adenosine A2A receptor blockade reverts hippocampal stress-induced deficits and restores corticosterone circadian oscillation

VL Batalha, JM Pêgo, BM Fontinha, AR Costenla… - Molecular …, 2013 - nature.com
Maternal separation (MS) is an early life stress model that induces permanent changes in
the central nervous system, impairing hippocampal long-term potentiation (LTP) and spatial …

Enhanced tau phosphorylation in the hippocampus of mice treated with 3, 4-methylenedioxymethamphetamine (“Ecstasy”)

CL Busceti, F Biagioni, B Riozzi… - Journal of …, 2008 - Soc Neuroscience
3, 4-Methylenedioxymethamphetamine (MDMA)(“Ecstasy”) produces neurotoxic effects,
which result into an impairment of learning and memory and other neurological …

Genetic and pharmacological inactivation of the adenosine A2A receptor attenuates 3‐nitropropionic acid‐induced striatal damage

JS Fink, A Kalda, H Ryu, EC Stack… - Journal of …, 2004 - Wiley Online Library
Abstract Adenosine A2A receptor (A2AR) antagonism attenuates 1‐methyl‐4‐phenyl‐1, 2, 3,
6‐tetrahydropyridine‐induced dopaminergic neurodegeneration and quinolinic acid …

Persistent MDMA‐induced dopaminergic neurotoxicity in the striatum and substantia nigra of mice

N Granado, E O'Shea, J Bove, M Vila… - Journal of …, 2008 - Wiley Online Library
Acute administration of repeated doses of 3, 4‐methylenedioxymethamphetamine (MDMA,
ecstasy) dramatically reduces striatal dopamine (DA) content, tyrosine hydroxylase (TH) …