The spongipyran macrolides, a new class of marine natural products, exhibit subnanomolar
antitumor activities against a number of human cancer cell lines. Independent …

First reported in 1993 by three groups (Kobayashi and Kitagawa, Pettit, and Fusetani),[1] the
altohyrtins/spongistatins/cinachyrolides are a unique family of antimitotic macrolides [2±5] …

The most active compound of the extraordinarily cytotoxic spongipyrans, spongistatin 1,
isolated from marine sponges, appeared to be identical to altohyrtin A. The total synthesis of …

The most active compound of the extraordinarily cytotoxic spongipyrans, spongistatin 1,
isolated from marine sponges, appeared to be identical to altohyrtin A. The total synthesis of …

The spongistatins comprise an important family of architecturally complex marine macrolides
that display extraordinary antitumor activities against a variety of human cancer cell lines …

The spongistatins comprise an architecturally unique family of macrolides that have attracted
wide interest in both the chemical and biomedical communities [1] as a consequence of their …

Fascinating structures and stunning cytotoxicities characterize the altohyrtins A–C, the
spongistatins 1–9, and cynachyrolide A. The first total syntheses reported by the groups from …

The synthesis of the highly substituted E and F pyran fragment 23 of altohyrtin A 1 from tri-O-
benzyl-D-glucal 5 is described. The synthesis of a model compound 31 containing the …

The first total synthesis of a spongipyran macrolide, altohyrtin C, is described. The
convergent synthesis strategy relies on a regioselective macrolactonization, a …

The C (18–28) CD-ring spiroketal subunit of the spongistatins, marine polyether macrolides
with unprecedented antitumor activity, has been generated via a highly convergent and …