Wdr5-mediated H3K4me3 coordinately regulates cell differentiation, proliferation termination, and survival in digestive organogenesis
Z Zhang, C Yang, Z Wang, L Guo, Y Xu, C Gao… - Cell Death …, 2023 - nature.com
Food digestion requires the cooperation of different digestive organs. The differentiation of
digestive organs is crucial for larvae to start feeding. Therefore, during digestive …
digestive organs is crucial for larvae to start feeding. Therefore, during digestive …
SETD7 controls intestinal regeneration and tumorigenesis by regulating Wnt/β-catenin and Hippo/YAP signaling
MJ Oudhoff, MJS Braam, SA Freeman, D Wong… - Developmental cell, 2016 - cell.com
Intestinal tumorigenesis is a result of mutations in signaling pathways that control cellular
proliferation, differentiation, and survival. Mutations in the Wnt/β-catenin pathway are …
proliferation, differentiation, and survival. Mutations in the Wnt/β-catenin pathway are …
Up‐regulated WDR5 promotes gastric cancer formation by induced cyclin D1 expression
W Sun, F Guo, M Liu - Journal of cellular biochemistry, 2018 - Wiley Online Library
Gastric cancer (GC) is the fourth common cancer and second leading cause of cancer‐
related mortality in the world. WD repeat domain 5 (WDR5) has been identified that its …
related mortality in the world. WD repeat domain 5 (WDR5) has been identified that its …
Jnk2 deletion disrupts intestinal mucosal homeostasis and maturation by differentially modulating RNA-binding proteins HuR and CUGBP1
HK Chung, JN Rao, T Zou, L Liu… - … of Physiology-Cell …, 2014 - journals.physiology.org
Homeostasis and maturation of the mammalian intestinal epithelium are preserved through
strict regulation of cell proliferation, apoptosis, and differentiation, but the exact mechanism …
strict regulation of cell proliferation, apoptosis, and differentiation, but the exact mechanism …
Histone H3K27me3 demethylases KDM6A and KDM6B modulate definitive endoderm differentiation from human ESCs by regulating WNT signaling pathway
Definitive endoderm differentiation is crucial for generating respiratory and gastrointestinal
organs including pancreas and liver. However, whether epigenetic regulation contributes to …
organs including pancreas and liver. However, whether epigenetic regulation contributes to …
The m6A Reader YTHDF1 Facilitates the Tumorigenesis and Metastasis of Gastric Cancer via USP14 Translation in an m6A-Dependent Manner
XY Chen, R Liang, YC Yi, HN Fan, M Chen… - Frontiers in cell and …, 2021 - frontiersin.org
Objectives N6-methyladenosine (m6A) RNA methylation is implicated in the progression of
multiple cancers via influencing mRNA modification. YTHDF1 can act as an oncogene in …
multiple cancers via influencing mRNA modification. YTHDF1 can act as an oncogene in …
PI3K/AKT-mediated upregulation of WDR5 promotes colorectal cancer metastasis by directly targeting ZNF407
X Tan, S Chen, J Wu, J Lin, C Pan, X Ying, Z Pan… - Cell death & …, 2017 - nature.com
Colorectal cancer (CRC) is the third most common cause of cancer deaths, and has a high
rate of liver and lung metastasis. Unfortunately, distant metastasis is the main barrier for …
rate of liver and lung metastasis. Unfortunately, distant metastasis is the main barrier for …
YTHDF 1‐mediated translation amplifies Wnt‐driven intestinal stemness
B Han, S Yan, S Wei, J Xiang, K Liu, Z Chen, R Bai… - EMBO …, 2020 - embopress.org
Abstract N6‐methyladenosine (m6A) mRNA methylation has emerged as an important
player in many biological processes by regulating gene expression. However, its roles in …
player in many biological processes by regulating gene expression. However, its roles in …
PKM2 controls the translation of TFE3 to maintain the integrity of the Golgi apparatus for the survival of HeLa and ME‐180 cervical cancer cells
Y Taguchi, K Ito, F Kano - The FEBS Journal, 2023 - Wiley Online Library
The M2 isoform of pyruvate kinase (PKM2) is abundantly expressed in various cancer cells
and associated with tumorigenesis, tumour proliferation and tumour progression. However …
and associated with tumorigenesis, tumour proliferation and tumour progression. However …
De-ubiquitinating enzymes USP21 regulate MAPK1 expression by binding to transcription factor GATA3 to regulate tumor growth and cell stemness of gastric cancer
Q Guo, D Shi, L Lin, H Li, Y Wei, B Li… - Frontiers in cell and …, 2021 - frontiersin.org
USP21 is a kind of deubiquitinating enzymes involved in the malignant progression of
various cancers, while its role in gastric cancer (GC) and the specific molecular mechanism …
various cancers, while its role in gastric cancer (GC) and the specific molecular mechanism …