Hypoxia is a hallmark of tumors leading to (mal-) adaptive processes, development of
aggressive phenotypes and treatment resistance. Based on underlying mechanisms and …

Tumor hypoxia is a hallmark of solid malignant tumor growth, profoundly influences
malignant progression and contributes to the development of therapeutic resistance …

Tissue hypoxia results from an inadequate supply of oxygen (O2) that compromises biologic
functions. Evidence from experimental and clinical studies increasingly points to a …

Hypoxia is present to some extent in most solid malignant human cancers because of an
imbalance between the limited oxygen delivery capacity of the abnormal vasculature and …

Hypoxia, a prevalent characteristic of most solid malignant tumors, contributes to diminished
therapeutic responses and more aggressive phenotypes. The term hypoxia has two …

Tumor hypoxia is a common feature of the microenvironment in solid tumors, primarily due to
an inadequate, and heterogeneous vascular network. It is associated with resistance to …

Tumour hypoxia is a major constraint for radiotherapy and many types of chemotherapy. A
variety of different pathogenetic mechanisms contribute to the development of hypoxia in …

Tumor hypoxia or a reduction of the tissue oxygen tension is a key microenvironmental
factor for tumor progression and treatment resistance in solid tumors. Because hypoxic …

Growing evidence from experimental and clinical studies points to the fundamental,
pathophysiologic role of hypoxia in solid tumors. Intratumoral hypoxia is a consequence of a …

There is an important and strong, but complex influence of the tumor microenvironment on
tumor cells׳ phenotype, aggressiveness, and treatment sensitivity. One of the most frequent …