Pulmonary injury and oxidative stress in rats induced by inhaled sulfur mustard is ameliorated by anti-tumor necrosis factor-α antibody

R Malaviya, A Bellomo, E Abramova… - Toxicology and applied …, 2021 - Elsevier
Sulfur mustard (SM) is a bifunctional alkylating agent that causes severe injury to the
respiratory tract. This is accompanied by an accumulation of macrophages in the lung and …

Inflammatory effects of inhaled sulfur mustard in rat lung

R Malaviya, VR Sunil, J Cervelli, DR Anderson… - Toxicology and applied …, 2010 - Elsevier
Inhalation of sulfur mustard (SM), a bifunctional alkylating agent that causes severe lung
damage, is a significant threat to both military and civilian populations. The mechanisms …

Mechanism underlying acute lung injury due to sulfur mustard exposure in rats

Z Xiaoji, M Xiao, X Rui, C Haibo… - Toxicology and …, 2016 - journals.sagepub.com
Sulfur mustard (SM), a bifunctional alkylating agent that causes severe lung damage, is a
significant threat to both military and civilian populations. The mechanisms mediating the …

Progressive lung injury, inflammation, and fibrosis in rats following inhalation of sulfur mustard

R Malaviya, EV Abramova, RC Rancourt… - Toxicological …, 2020 - academic.oup.com
Sulfur mustard (SM) inhalation causes debilitating pulmonary injury in humans which
progresses to fibrosis. Herein, we developed a rat model of SM toxicity which parallels …

Sulfur mustard-induced pulmonary injury: therapeutic approaches to mitigating toxicity

B Weinberger, JD Laskin, VR Sunil, PJ Sinko… - Pulmonary …, 2011 - Elsevier
Sulfur mustard (SM) is highly toxic to the lung inducing both acute and chronic effects
including upper and lower obstructive disease, airway inflammation, and acute respiratory …

Evaluation of protease inhibitors and an antioxidant for treatment of sulfur mustard-induced toxic lung injury

DR Anderson, SL Taylor, DP Fetterer, WW Holmes - Toxicology, 2009 - Elsevier
Sulfur mustard (SM)-induced lung injury has been associated with protease activation,
oxidative injury and inflammatory response culminating in tissue necrosis. The protease …

A review of sulfur mustard-induced pulmonary Immunopathology: an alveolar macrophage approach

S Sadeghi, M Tapak, T Ghazanfari, N Mosaffa - Toxicology Letters, 2020 - Elsevier
Despite many studies investigating the mechanism of Sulfur Mustard (SM) induced lung
injury, the underlying mechanism is still unclear. Inflammatory and subsequent …

In vitro the differences of inflammatory and oxidative reactions due to sulfur mustard induced acute pulmonary injury underlying intraperitoneal injection and …

D Yu, Y Bei, Y Li, W Han, Y Zhong, F Liu, Y Zhao… - International …, 2017 - Elsevier
This study was to investigate the differences of inflammatory reaction and oxidative stress
due to sulfur mustard (SM)-induced acute pulmonary injury via two ways in rats. In …

Sulfur mustard inhalation induced respiratory lesions in guinea pigs: Physiological, biochemical, and histological study

N Allon, E Gilat, A Amir, E Fishbine, H Liani - 1993 - osti.gov
Inhalation exposure to sulfur mustard (SM) vapor causes long term damage to the
respiratory system. The lesions were characterized by specific physiological, biochemical …

Role of oxidative stress in sulfur mustard-induced pulmonary injury and antioxidant protection

E Tahmasbpour, S Reza Emami, M Ghanei… - Inhalation …, 2015 - Taylor & Francis
Sulfur mustard (SM) is a potent alkylating agent that targets several organs, especially lung
tissue. Although pathological effects of SM have been widely considered, molecular and …