Congenital central hypoventilation syndrome (CCHS) has been thought to be a disorder of
central chemoreceptor responsiveness. Previous studies in CCHS have shown decreased …

Central chemoreceptors appear to be widely distributed in the brainstem. Why are there so
many central chemoreceptor sites? This review focuses on two hypotheses.(1) The high …

This study tested the hypothesis that ventilatory responses to chemoreceptor stimulation are
affected by the level of arterial pressure and degree of baroreceptor activation. Carotid …

The sympathetic adjustments triggered by acute mild hypoxia (sympathetic chemoreflex) are
initiated by activation of peripheral chemoreceptors whereas more severe hypoxia activates …

The paired-like homeobox 2B gene (PHOX2B) is the disease-defining gene for congenital
central hypoventilation syndrome (CCHS). Individuals with CCHS typically present in the …

Congenital central hypoventilation syndrome (CCHS) patients show deficient respiratory
and cardiac responses to hypoxia and hypercapnia, despite apparently intact arousal …

The regulation of breathing relies upon chemical feedback concerning the levels of CO2 and
O2. The carotid bodies, which detect O2, provide tonic excitation to brainstem respiratory …

Paton, Julian FR Pattern of cardiorespiratory afferent convergence to solitary tract neurons
driven by pulmonary vagal C-fiber stimulation in the mouse. J. Neurophysiol. 79: 2365 …

Congenital central hypoventilation syndrome (CCHS) is a rare disorder of unknown etiology,
characterized by failure of the autonomic control of respiration. The primary defect is …

Key points Central chemoreceptor stimulation, by hypercapnia (acidosis), and peripheral, by
hypoxia plus hypercapnia, evoke reflex increases in ventilation and sympathetic outflow …