Background: Intratumoral hypoxia is known to lead to increased aggressiveness and distant
metastasis. However, the interplay underlying these actions is still unknown. Objective: We …

Purpose: Pancreatic cancer is characterized by intratumoral hypoxia, early and aggressive
local invasion, and metastatic potential. Hypoxia-inducible factor-1 (HIF-1) is the major …

Hypoxia is known to play critical roles in cell survival, angiogenesis, tumor invasion, and
metastasis. Hypoxia mediated over-expression of hypoxia-inducible factor (HIF) has been …

Gastric cancers are one of the most common gastrointestinal tumors with proclivity to
metastasis. Hypoxia is an important feature in solid tumor microenvironment; accumulating …

In the tumor cells exposed to hypoxia, hypoxia-inducible factor-1 (HIF-1)-mediated
adaptation responses such as angiogenesis and anaerobic metabolism are induced for their …

Intratumoral heterogeneity is an important factor contributing to metastasis and therapy
resistance. The phenotypic diversity of cancer cells within the tumor microenvironment is …

Hypovasculature is an outstanding characteristic of pancreatic cancers in imaging
diagnosis, suggesting that blood supply is poor in pancreatic cancer tissues. Despite poor …

Pancreatic cancer is one of the common malignant tumors of the digestive system and is
known as the “king of cancers”. It is extremely difficult to diagnose at an early stage, the …

The correlation between hypoxia and pancreatic cancer has long been discussed. Hao's
research team made many efforts on revealing the oncogenic function of hypoxic inducible …

Intratumoral hypoxia is a common feature of solid tumors. Recent advances in cancer
biology indicate that hypoxia is not only a consequence of unrestrained tumor growth, but …