Ligands with the polysaccharide headgroups have been recently reported by our group to
possess enhanced interaction with asialoglycoprotein receptor (ASGPR) in silico as …

Since the asialoglycoprotein receptor (also known as the “Ashwell–Morell receptor” or
ASGPR) was discovered as the first cellular mammalian lectin, numerous drug delivery …

Targeted-drug administration to liver reduces side effects by minimising drug distribution to
non-target organs and increases therapeutic efficacy by boosting drug concentration in …

Hepatocyte resident afflictions continue to affect the human population unabated. The
asialoglycoprotein receptor (ASGPR) is primarily expressed on hepatocytes and minimally …

Asialoglycoprotein receptors (ASGPR) are hepatocyte bound receptors, which exhibit
receptor mediated endocytosis (RME) for galactose specific moieties. Arabinogalactan (AG) …

Targeted delivery of therapeutic agents to hepatocytes is a particularly attractive strategy for
the treatment of hepatocellular carcinoma and other liver diseases. The asialoglycoprotein …

We have developed active targeting liposomes to deliver anticancer agents to ASGPR which
will contribute to effective treatment of hepatocellular carcinoma. Active targeting is achieved …

The asialoglycoprotein-receptor (ASGP-R) is a C-type lectin predominantly expressed on
the sinusoidal surface of mammalian hepatocytes and is responsible for the blood-clearance …

In order to develop the non-viral Bioplex vector system for targeted delivery of genes to
hepatocytes, we have evaluated the structure-function relationship for a number of synthetic …

The coiled-coil folding motif represents an ideal scaffold for the defined presentation of
ligands due to the possibility of positioning them at specific distances along the axis. We …