A plasma factor displaying permeability activity in vitro and possibly determining proteinuria
has been hypothesized in idiopathic focal segmental glomerulosclerosis (FSGS). In vitro …

Podocin is a critical component of the glomerular slit diaphragm, and genetic mutations lead
to both familial and sporadic forms of steroid-resistant nephrotic syndrome. In mice …

In situ evaluation of podocin in normal and glomerular diseases. Background Mutations of
the NPHS2 gene are responsible for autosomal-recessive steroid-resistant nephrotic …

Focal segmental glomerulosclerosis (FSGS) is the primary renal disease in approximately
one-tenth of pediatric patients receiving a renal allograft. Recurrence of proteinuria after …

In vivo expression of podocyte slit diaphragm-associated proteins in nephrotic patients with
NPHS2 mutation. Background Mutations in NPHS2, encoding podocin, are a prevalent …

Recurrent focal glomerulosclerosis (FSGS) in renal al-lografts has remained a frustrating
and enigmatic dis-ease. Recent studies on gene mutations encoding podocin and other …

Disease-causing missense mutations in NPHS2 gene alter normal nephrin trafficking to the
plasma membrane. Background Podocin is a membrane-integrated protein that is located at …

Monogenic disorders result from defects in a single gene. According to Mendel's laws, these
disorders are inherited in either a recessive or dominant fashion. Autosomal-recessive …

To the Editor: Podocin is a key component of the podocyte slit diaphragm. Mutations of
podocin cause recessive steroid-resistant nephrotic syndrome that evolves to renal failure in …

Background. Focal segmental glomerulosclerosis (FSGS) is a major cause of steroid-
resistant nephrotic syndrome in childhood with a central role for the podocytes in the …