Our understanding of focal and segmental glomerulosclerosis (FSGS) has advanced
significantly from the studies of rare, monogenic forms of the disease. These studies have …

Primary steroid-resistant nephrotic syndrome (SRNS) is characterized by childhood onset of
proteinuria and progression to end-stage renal disease. In 26% of cases it is caused by …

Studies of Mendelian forms of focal segmental glomerulosclerosis (FSGS) and nephrotic
syndrome have provided new insights into the mechanism of these diseases. Congenital …

Advances in podocytology and genetic techniques have expanded our understanding of the
pathogenesis of hereditary steroid-resistant nephrotic syndrome (SRNS). In the past 20 …

Recent progress in defining the genetic basis of inherited glomerular disease has helped
illuminate inadequacies in the way we describe many of these diseases. Too often, we talk …

Clinical Features and Long-Term Outcome of Nephrotic Syndrom... : Clinical Journal of the
American Society of Nephrology Clinical Features and Long-Term Outcome of Nephrotic …

Nephrotic syndrome (NS) is the most frequent cause of proteinuria in children and is
emerging as a leading cause of uremia. Molecular studies in families with recessive NS …

Focal segmental glomerulosclerosis (FSGS) is one of the most common forms of acquired
glomerular disease leading to end-stage kidney disease. Its incidence is rising around the …

Mutations in NPHS1, which encodes nephrin, are the main causes of congenital nephrotic
syndrome (CNS) in Finnish patients, whereas mutations in NPHS2, which encodes podocin …

The NPHS2 gene encoding the podocin protein was causally linked to the autosomal
recessive type of steroid-resistant nephrotic syndrome. In this study, we investigated the …