The terms minimal change nephropathy and focal segmental glomerulosclerosis describe
histopathological entities diagnosed by renal biopsy, typically in patients presenting with …

Background and objectives: Mutations in podocyte genes are associated with steroid-
resistant nephrotic syndrome (SRNS), mostly affecting younger age groups. To date, it is …

Podocytes are specialized epithelial cells covering the basement membrane of the
glomerulus in the kidney. The molecular mechanisms underlying the role of podocytes in …

A spectrum of proteinuric glomerular diseases results from podocyte abnormalities. The
understanding of these podocytopathies has greatly expanded in recent years, particularly …

Podocin is identified as a product of the gene mutated in a patient with autosomal recessive
steroid-resistant nephrotic syndrome. Although podocin is reported to be located at the slit …

Nephrotic syndrome (NS) is a common pediatric kidney disease and is defined as massive
proteinuria, hypoalbuminemia, and edema. Dysfunction of the glomerular filtration barrier …

This review deals with podocyte proteins that play a significant role in the structure and
function of the glomerular filter. Genetic linkage studies has identified several genes …

Results Steroid-resistant nephrotic syndrome manifested in the first 5 years of life in 64% of
the patients. Congenital nephrotic syndrome accounted for 6% of all patients. Extrarenal …

Focal segmental glomerulosclerosis (FSGS) is a major cause of idiopathic steroid-resistant
nephrotic syndrome (SRNS) and end-stage kidney disease (ESKD). In recent years, animal …

Proteinuria is a poorly understood feature of many acquired renal diseases. Recent studies
concerning congenital nephrotic syndromes and findings in genetically modified mice have …