[HTML][HTML] Cryptococcal immune reconstitution inflammatory syndrome: from blood and cerebrospinal fluid biomarkers to treatment approaches

VMS Brienze, JC André, E Liso, I Vlasova-St. Louis - Life, 2021 - mdpi.com
Immune reconstitution inflammatory syndrome (IRIS) presents as an exaggerated immune
reaction that occurs during dysregulated immune restoration in immunocompromised …

[PDF][PDF] Cryptococcal meningitis in an HIV-1-infected person: relapses or IRIS? Case report and review of the literature.

G Nunnari, M Gussio, MR Pinzone… - European Review for …, 2013 - europeanreview.org
After starting highly active antiretro-viral therapy (HAART), HIV-infected patients may
experience what is termed immune reconstitution inflammatory syndrome (IRIS). IRIS is …

Central nervous system immune reconstitution inflammatory syndrome

N Bahr, DR Boulware, S Marais, J Scriven… - Current infectious …, 2013 - Springer
Central nervous system immune reconstitution inflammatory syndrome (CNS-IRIS) develops
in 9%–47% of persons with HIV infection and a CNS opportunistic infection who start …

Cryptococcus-Related Immune Reconstitution Inflammatory Syndrome (IRIS): Pathogenesis and its Clinical Implications

DL Wiesner, DR Boulware - Current fungal infection reports, 2011 - Springer
This review provides an overview of Cryptococcus neoformans immunology and focuses on
the pathogenesis of Cryptococcus-related paradoxical immune reconstitution inflammatory …

Plasma but not cerebrospinal fluid interleukin 7 and interleukin 5 levels pre–antiretroviral therapy commencement predict cryptococcosis-associated immune …

NA Akilimali, CC Chang, DM Muema… - Clinical Infectious …, 2017 - academic.oup.com
Background Patients with human immunodeficiency virus/AIDS-associated cryptococcal
meningitis (CM) frequently experience clinical deterioration, known as cryptococcosis …

Shedding light on IRIS: from Pathophysiology to Treatment of Cryptococcal Meningitis and Immune Reconstitution Inflammatory Syndrome in HIV‐Infected Individuals

A Balasko, Y Keynan - HIV medicine, 2019 - Wiley Online Library
Objectives The aim of this work was to review current treatment options and propose
alternatives for immune reconstitution inflammatory syndrome (IRIS) in HIV‐infected …

[HTML][HTML] Clinical features and serum biomarkers in HIV immune reconstitution inflammatory syndrome after cryptococcal meningitis: a prospective cohort study

DR Boulware, DB Meya, TL Bergemann… - PLoS …, 2010 - journals.plos.org
Background Although antiretroviral therapy (ART) improves survival in persons with
cryptococcal meningitis (CM) and AIDS, ART frequently elicits HIV immune reconstitution …

Understanding causal pathways in cryptococcal meningitis immune reconstitution inflammatory syndrome

JN Jarvis, TS Harrison - The Journal of infectious diseases, 2019 - academic.oup.com
Human immunodeficiency virus (HIV)-associated cryptococcal meningitis continues to pose
a major clinical challenge. Mortality rates of 20%–40% have been reported in recent clinical …

[HTML][HTML] Hiv-associated cryptococcal immune reconstitution inflammatory syndrome is associated with aberrant t cell function and increased cytokine responses

DB Meya, S Okurut, G Zziwa, S Cose, DR Boulware… - Journal of Fungi, 2019 - mdpi.com
Cryptococcal meningitis remains a significant opportunistic infection among HIV-infected
patients, contributing 15–20% of HIV-related mortality. A complication of initiating …

Transcriptomic predictors of paradoxical cryptococcosis-associated immune reconstitution inflammatory syndrome

I Vlasova-St. Louis, CC Chang, S Shahid… - Open forum …, 2018 - academic.oup.com
Background Paradoxical cryptococcosis-associated immune reconstitution inflammatory
syndrome (C-IRIS) affects~ 25% of human immunodeficiency virus (HIV)-infected patients …