Introduction: A major problem with conventional antitumor therapeutics is nonselective
delivery of cytotoxic drugs to normal vital organs and tissues but little delivery to tumor …

Over the past two decades cancer has ascended the causes of human death to be number
one or two in many nations world wide. A major limitation inherent to most conventional …

Enhanced permeability and retention (EPR) effect is the physiology-based principal
mechanism of tumor accumulation of large molecules and small particles. This specific issue …

The enhanced permeability and retention (EPR) effect is a unique phenomenon of solid
tumors that is related to their particular anatomical and pathophysiological characteristics …

Chemotherapy for human solid tumors in clinical practice is far from satisfactory. Despite the
discovery and synthesis of hundreds of thousands of anticancer compounds targeting …

Effective cancer therapy remains one of the most challenging tasks to the scientific
community, with little advancement on overall cancer survival landscape during the last two …

Over the past three decades, the enhanced permeability and retention (EPR) effect has
been considered the basis of tumor-targeted drug delivery. Various cancer nanomedicines …

This Special Issue on the enhanced permeability and retention (EPR) effect commemorates
the 35th anniversary of its discovery, the original 1986 Matsumura and Maeda finding being …

Enhanced permeability of the tumor vasculature allows macromolecules to enter the tumor
interstitial space, whereas the suppressed lymphatic filtration allows them to stay there. This …

Nano-sized therapeutic agents have several advantages over low molecular weight agents
such as a larger loading capacity, the ability to protect the payload until delivery, more …