Type 1 diabetes mellitus (T1DM) is an autoimmune disease that involves the progressive
destruction of the insulin-producing β cells in the islets of langerhans. It is a complex process …

Conclusion Type I diabetes is an autoimmune disease heralded by T cell-mediated
destruction of pancreatic islet β cells. The mechanism (s) involved in this β-cell destruction is …

Summary Type 1 diabetes (T1D) develops when there are insufficient insulin-producing beta
cells to maintain glucose homeostasis. The prevailing view has been that T1D is caused by …

Type 1 diabetes is an autoimmune disease characterised by the destruction of insulin
producing beta cells in the pancreas. Whilst it remains unclear what the original triggering …

Insulin dependent diabetes mellitus is a T-cell mediated autoimmune disease. Several β-cell
antigens, mostly non-tissue-specific, have been implicated in the disease process. The …

Although the pathogenesis of diabetes mellitus remains an enigma, a consensus has
emerged over the last decade regarding several important biologic characteristics of this …

Whether autoimmunity results primarily from a defect of the immune system, target organ
dysfunction, or both remains an open issue in most human autoimmune diseases. The …

Type 1 diabetes mellitus is perceived as a chronic immunemediated disease with a
subclinical prodromal period characterized by selective loss of insulin-producing beta cells …

Around 1960, observations of lymphocytic insulitis and the presence of islet cell
autoantibodies in patients with type 1 diabetes led to the concept of type 1 diabetes being an …

Type 1 diabetes mellitus results from a T-cell mediated autoimmune destruction of the
pancreatic beta cells in genetically predisposed individuals. The knowledge of the …