Platelet degranulation allows the release of a large amount of soluble mediators, is an
essential step for wound healing initiation, and stimulates clotting, and angiogenesis. The …

BACKGROUND: While single growth factor has limitation to induce optimal
neovascularization, platelet-rich plasma (PRP) is an autologous reserver of various growth …

Platelets are known for their role in haemostasis where they help prevent blood loss at sites
of vascular injury. To do this, they adhere, aggregate and form a procoagulant surface …

Platelet derivatives are commonly used in wound healing and tissue regeneration. Different
procedures of platelet preparation may differentially affect growth factor release and cell …

Platelets play a crucial role in hemostasis, tissue regeneration and host defense. Based on
these settings, platelet-rich plasma (PRP) and its derivatives are therapeutically used to …

Prior preclinical and clinical studies support the use of platelet-derived products for the
treatment of soft and hard tissue lesions. These regenerative effects are controlled by …

Orthobiologics continue to gain popularity in many areas of medical science, especially in
the field of regenerative medicine. Platelet-rich plasma derivatives are orthobiologic tools of …

The preponderance of evidence indicates that platelets and their derivatives have the
potential for a substantial therapeutic role in tissue regeneration. The results of recent …

Platelet-rich fibrin (PRF) represents second generation of platelet concentrates, which has
gained increasing awareness in recent years for regenerative procedures. This biologic …

Platelets produce platelet growth factors such as PDGF, IGF-1, EGF-, HGF, TGFβ, bFGF, and
VEGF, which are crucial in regulating all stages of the wound healing process. The source of …