Effects of flavonoids on matrix metalloproteinase-13 expression of interleukin-1β–treated articular chondrocytes and their cellular mechanisms: inhibition of c-Fos/AP-1 …
H Lim, H Park, HP Kim - Journal of pharmacological sciences, 2011 - Elsevier
To identify the therapeutic potential for cartilage degradation and its action mechanisms, the
effects of naturally-occurring flavonoids on matrix metalloproteinase-13 (MMP-13) induction …
effects of naturally-occurring flavonoids on matrix metalloproteinase-13 (MMP-13) induction …
[HTML][HTML] Oleocanthal inhibits catabolic and inflammatory mediators in LPS-activated human primary osteoarthritis (OA) chondrocytes through MAPKs/NF-κB pathways
M Scotece, J Conde, V Abella, V López… - Cellular Physiology and …, 2018 - karger.com
Background/Aims: Oleocanthal (OC), a phenolic compound present in extra virgin olive oil
(EVOO), has attracted attention since its discovery for its relevant pharmacological …
(EVOO), has attracted attention since its discovery for its relevant pharmacological …
Novel selective MMP-13 inhibitors reduce collagen degradation in bovine articular and human osteoarthritis cartilage explants
D Piecha, J Weik, H Kheil, G Becher… - Inflammation …, 2010 - Springer
Objective MMP-13 is highly upregulated in arthritis and therefore strongly implicated in the
pathogenesis of osteoarthritis (OA). Selective inhibition of MMP-13 may provide the desired …
pathogenesis of osteoarthritis (OA). Selective inhibition of MMP-13 may provide the desired …
[HTML][HTML] ADAMTS5 in osteoarthritis: biological functions, regulatory network, and potential targeting therapies
L Jiang, J Lin, S Zhao, J Wu, Y Jin, L Yu… - Frontiers in molecular …, 2021 - frontiersin.org
ADAMTS5 is involved in the pathogenesis of OA. As the major aggrecanase-degrading
articular cartilage matrix, ADAMTS5, has been regarded as a potential target for OA …
articular cartilage matrix, ADAMTS5, has been regarded as a potential target for OA …
[HTML][HTML] Upper zone of growth plate and cartilage matrix associated protein protects cartilage during inflammatory arthritis
F Seuffert, D Weidner, W Baum, G Schett… - Arthritis Research & …, 2018 - Springer
Background ADAMTS aggrecanases play a major role in cartilage degeneration during
degenerative and inflammatory arthritis. The cartilage-specific secreted protein Upper zone …
degenerative and inflammatory arthritis. The cartilage-specific secreted protein Upper zone …
Expression profiling of metalloproteinases and their inhibitors in cartilage
L Kevorkian, DA Young, C Darrah… - … : Official Journal of …, 2004 - Wiley Online Library
Objective To profile the expression of all known members of the matrix metalloproteinase
(MMP), ADAMTS, and tissue inhibitor of metalloproteinases (TIMP) gene families in normal …
(MMP), ADAMTS, and tissue inhibitor of metalloproteinases (TIMP) gene families in normal …
A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: Evidence of histologic and clinical efficacy without musculoskeletal …
VM Baragi, G Becher, AM Bendele… - … : Official Journal of …, 2009 - Wiley Online Library
Abstract Objective Matrix metalloproteinases (MMPs) have long been considered excellent
targets for osteoarthritis (OA) treatment. However, clinical utility of broad‐spectrum MMP …
targets for osteoarthritis (OA) treatment. However, clinical utility of broad‐spectrum MMP …
[HTML][HTML] Rhein, an active metabolite of diacerein, down-regulates the production of pro-matrix metalloproteinases-1,-3,-9 and-13 and up-regulates the production of …
T Tamura, N Kosaka, J Ishiwa, T Sato, H Nagase… - Osteoarthritis and …, 2001 - Elsevier
Objective Diacerein has proved to be effective in the treatment of osteoarthritis (OA).
However, the precise action mechanism of diacerein on OA is not yet fully understood …
However, the precise action mechanism of diacerein on OA is not yet fully understood …
Identification of potent and selective hydantoin inhibitors of aggrecanase-1 and aggrecanase-2 that are efficacious in both chemical and surgical models of …
TB Durham, VJ Klimkowski, CJ Rito… - Journal of Medicinal …, 2014 - ACS Publications
A disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4) and
ADAMTS-5 are zinc metalloproteases commonly referred to as aggrecanase-1 and …
ADAMTS-5 are zinc metalloproteases commonly referred to as aggrecanase-1 and …
Cartilage degradation biomarkers predict efficacy of a novel, highly selective matrix metalloproteinase 13 inhibitor in a dog model of osteoarthritis: confirmation by …
S Settle, L Vickery, O Nemirovskiy… - Arthritis & …, 2010 - Wiley Online Library
Objective To demonstrate that the novel highly selective matrix metalloproteinase 13 (MMP‐
13) inhibitor PF152 reduces joint lesions in adult dogs with osteoarthritis (OA) and …
13) inhibitor PF152 reduces joint lesions in adult dogs with osteoarthritis (OA) and …