While genetic perturbation has been the conventional route to probing bacterial systems,
small molecules are showing great promise as probes for cellular complexity. Indeed …

Conspectus Drug-resistant bacterial infections pose an imminent and growing threat to
public health. The discovery and development of new antibiotics of novel chemical class and …

Recent genome-scale analyses of genetic interactions in model microbes have revealed the
inherent functional organization of the cell as a dense network of highly interconnected …

The explosion of sequence information in bacteria makes developing high-throughput, cost-
effective approaches to matching genes with phenotypes imperative. Using E. coli as proof …

Advances in sequencing technology have provided an unprecedented view of bacterial
diversity, along with a daunting number of novel genes. Within this new reality lies the …

Chemical genomics expands our understanding of microbial tolerance to inhibitory
chemicals, but its scope is often limited by the throughput of genome-scale library …

Drug combinations are increasingly important in disease treatments, for combating drug
resistance, and for elucidating fundamental relationships in cell physiology. When drugs are …

Here, we review the'target-centric'genomic strategy to antimicrobial discovery and share our
perspective on identification, validation and prioritization of potential antimicrobial drug …

While cell-based screens have considerable power in identifying new chemical probes of
biological systems and leads for new drugs, a major challenge to the utility of such …

Antibiotic combinations are considered a relevant strategy to tackle the global antibiotic
resistance crisis since they are believed to increase treatment efficacy and reduce …