The development of new treatments for substance use disorders requires identification of
targetable molecular mechanisms. Pathology in glutamatergic neurotransmission system in …

Cocaine, amphetamine, and methamphetamine abuse disorders are serious worldwide
health problems. To date, there are no FDA-approved medications for the treatment of these …

Emerging evidence indicates that many aspects of alcohol and drug dependence involve
changes in glutamate transmission. A number of studies have reported that drugs of abuse …

Well-developed cellular mechanisms exist to preserve glutamate homeostasis and regulate
extrasynaptic glutamate levels. Accumulating evidence indicates that disruptions in …

Downregulation of the astroglial glutamate transporter GLT-1 is observed in the nucleus
accumbens (NAc) following administration of multiple drugs of abuse. The decrease in GLT …

Glutamate transmission is an important mediator of the development of substance use
disorders, particularly with regard to relapse. The present review summarizes the changes in …

Drug addiction has often been described as a “hijacking” of the brain circuits involved in
learning and memory. Glutamate is the principal excitatory neurotransmitter in the brain, and …

Relapse to cocaine-seeking behavior requires an increase in nucleus accumbens (NAc)
core glutamate transmission. Decreased expression of glutamate type I transporter (GLT1) …

Abstract l-Glutamate is the predominant excitatory neurotransmitter in the central nervous
system (CNS) and is directly and indirectly involved in a variety of brain functions. Glutamate …

The vesicular glutamate (GLU) transporter (VGLUT1) is a critical component of glutamatergic
neurons that regulates GLU release. Despite the likely role of GLU release in drug abuse …