Rationale Several studies have demonstrated a correlation between extracellular glutamate
concentration in the mesolimbic reward pathway and alcohol craving. Extracellular …

We show here that clozapine, a beneficial antipsychotic, down-regulates the expression of
the glutamate transporter GLT-1 in the rat cerebral cortex, thereby reducing glutamate …

A growing body of evidence suggests that activation of the glutamatergic system, particularly
N-methyl-d-aspartate (NMDA) receptor function, may be a viable approach to the treatment …

Glutamate is the principal excitatory neurotransmitter in the central nervous system and its
actions are related to the behavioral effects of psychostimulant drugs. In the last two …

Addiction is associated with neuroplasticity in the corticostriatal brain circuitry that is
important for guiding adaptive behaviour. The hierarchy of corticostriatal information …

Tonically active cholinergic interneurons (TANs) from the nucleus accumbens (NAc) are
centrally involved in reward behavior. TANs express a vesicular glutamate transporter …

The solute carrier family 1 (SLC1) consists of two neutral amino acid transporters and five
high-affinity excitatory amino acid transporters (EAAT1-5). EAATs are expressed in glial cells …

Alcohol dependence is associated with alteration of glutamate transport and glutamate
neurotransmission. Glutamate transporter 1 (GLT-1) is a major transporter that regulates the …

There are several lines of evidence implying the involvement of the central glutamatergic
system in morphine dependence. Extracellular glutamate released from nerve terminals is …

Glutamate signaling plays a major role in addiction. Preclinical research strongly suggests
an implication of G-protein-coupled metabotropic glutamate receptor subtype 5 (mGluR5) in …