Accumbal glycine modulates basal and ethanol-induced dopamine levels in the nucleus
accumbens (nAc) as well as voluntary ethanol consumption. Also, systemic administration of …

Glutamate is the predominant excitatory neurotransmitter in the mammalian central nervous
system and is critical for essentially all physiological processes ranging from control of motor …

Highlights•NAcore astrocytes undergo morphological remodeling after addictive drug use
resulting in their reduced synaptic proximity.•Repeated self-administration of …

The glutamate transporter (GLT1) regulates glutamate concentrations in glutamatergic
synapses and it is expressed in at least two isoforms, GLT1a and GLT1b. In this work, we …

Substance dependence is characterized by a group of symptoms, according to the
Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision (DSM-IV …

Drug addiction is characterized by drug-induced positive affect, followed by withdrawal-
associated negative affect. Such drug-induced positive and negative affective states provide …

Pathological gambling or gambling disorder has been defined by the DSM‐5 as a
behavioral addiction. To date, its pathophysiology is not completely understood and there is …

We analyzed global patterns of expression in genes related to glutamatergic
neurotransmission (glutamatergic genes) in healthy human adult brain before determining …

A major challenge in neuroscience is to resolve the connection between gene functionality,
neuronal circuits, and behavior. Most, if not all, neuronal circuits of the adult brain contain a …

Glutamate neurotransmission is highly regulated, largely by glutamate transporters. In the
spinal cord, the glutamate transporter GLT-1 is primarily responsible for glutamate …