The solute carrier family 1 (SLC1) is composed of five high affinity glutamate transporters,
which exhibit the properties of the previously described system XAG−, as well as two Na+ …

Cocaine addiction is characterized by overwhelming craving for the substance, which drives
its escalating use despite adverse consequences. Animal models suggest a disrupted …

Drug addiction is characterized by maladaptive decision-making and dysfunctional brain
circuitry regulating motivated behaviors, resulting in loss of the behavioral flexibility needed …

L-glutamate is the principal excitatory neurotransmitter at fast synapses in the mammalian
central nervous system, and signals though a number of ionotropic and metabotropic …

GLT-1, the major glutamate transporter in the mammalian central nervous system, is
expressed in presynaptic terminals that use glutamate as a neurotransmitter, in addition to …

Neurons responsible for sensing noxious stimuli and conducting pain signals from periphery
to the spinal cord are predominantly glutamatergic. Members of the SLC1A family of high …

Synaptically released l-glutamate, the most important excitatory neurotransmitter in the CNS,
is removed from extracellular space by fast and efficient transport mediated by several …

The glutamate transporter GLT-1 is highly expressed in astrocytes but also in neurons,
primarily in axon terminals. We generated a conditional neuronal GLT-1 KO using synapsin …

GLT1 is one of the major transporters responsible for maintenance of glutamate
homeostasis in the brain. In the present study, glutamate transporter 1-deficient GLT1 …

GLT-1 is the predominant glutamate transporter in most brain regions and therefore plays a
major role in terminating synaptic transmission and protecting neurons from glutamate …