Modulation of group II metabotropic glutamate receptor signaling by chronic cocaine

ZX Xi, S Ramamoorthy, DA Baker, H Shen… - … of Pharmacology and …, 2002 - ASPET
Repeated cocaine produces enduring neuroadaptations in glutamate transmission in the
nucleus accumbens that are thought to contribute to addiction. Group II metabotropic …

Translating glutamate: from pathophysiology to treatment

DC Javitt, D Schoepp, PW Kalivas, ND Volkow… - Science translational …, 2011 - science.org
The neurotransmitter glutamate is the primary excitatory neurotransmitter in mammalian
brain and is responsible for most corticocortical and corticofugal neurotransmission …

Rescue of glutamate transport in the lateral habenula alleviates depression-and anxiety-like behaviors in ethanol-withdrawn rats

S Kang, J Li, A Bekker, JH Ye - Neuropharmacology, 2018 - Elsevier
Alcoholism and psychiatric disorders like depression and anxiety are often comorbid.
Although the mechanisms underlying this comorbidity are unclear, emerging evidence …

Gene transfer of GLT‐1, a glutamate transporter, into the nucleus accumbens shell attenuates methamphetamine‐and morphine‐induced conditioned place …

M Fujio, T Nakagawa, Y Sekiya… - European Journal of …, 2005 - Wiley Online Library
Several lines of evidence have suggested that the glutamatergic system in the nucleus
accumbens (NAc) plays an important role in the conditioned rewarding effect of drugs of …

The role of astrocytic glutamate transporters GLT-1 and GLAST in neurological disorders: Potential targets for neurotherapeutics

E Pajarillo, A Rizor, J Lee, M Aschner, E Lee - Neuropharmacology, 2019 - Elsevier
Glutamate is the primary excitatory neurotransmitter in the central nervous system (CNS)
which initiates rapid signal transmission in the synapse before its re-uptake into the …