Epithelial damage is an important pathophysiologic feature of asthma. Bronchial epithelium
damage results in release of growth factors such as transforming growth factor (TGF)-β1 that …

COX-12 and-2 metabolize AA and other 20-carbon polyunsaturated fatty acids into PGs,
which have a wide array of biological roles that are tissue-specific (1). A variety of …

Cyclooxygenase-2 (COX-2)-mediated prostaglandin synthesis has recently been implicated
in human cholangiocarcinogenesis. This study was designed to examine the mechanisms …

COX is the key enzyme in the conversion of arachidonic acid to prostanoids, potent bioactive
lipid derivatives that participate in normal growth responses and in aberrant cellular growth …

Background Cyclooxygenase-2-derived prostaglandin E 2 (PGE 2), a bioactive eicosanoid,
has been implicated in many biological processes including reproduction, inflammation and …

Both cyclooxygenase (COX)-2 and epidermal growth factor receptor (EGFR) are thought to
play important roles in the pathogenesis of non-small cell lung cancer (NSCLC). A number …

Dysregulated amphiregulin (AR) expression and EGR receptor (EGFR) activation have been
described in animal models of pulmonary fibrosis and in patients with idiopathic pulmonary …

Transforming growth factor-ß1 (TGF-β1) is a multifunctional cytokine that is involved in
various pathophysiological processes, including cancer progression and fibrotic disorders …

Tumor cyclooxygenase-2 (COX-2) expression is known to be associated with enhanced
tumor invasiveness. In the present study, we evaluated the importance of the COX-2 product …

Constitutive overexpression of cyclooxygenase-2 (COX-2) occurs frequently in several
different malignancies, including lung, colon, breast, and prostate cancer. Clinical studies …