Cigarette smoking can lead to many human pathologies including cardiovascular and
respiratory disease. Recent studies have defined a role for fibroblasts in the development of …

Purpose: To determine the effect of taxane-based chemotherapy on intratumoral levels of
cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) in patients with non–small cell …

Lung cancer is the leading cause of cancer death in the USA. Conventional therapy using
chemotherapy, radiation therapy, and a combination of the two, has yielded modest …

Background Sex differences in idiopathic pulmonary fibrosis (IPF) suggest a protective role
for estrogen (E2); however, mechanistic studies in animal models have produced mixed …

COX-2 has been implicated in the control of human non-small cell lung carcinoma (NSCLC)
cell growth. The mechanisms by which COX-2 exerts its mitogenic effects have not been …

Lung cancer is the leading cause of cancer death all over the world. The low 5-year survival
rate (under 15%) has changed minimally in the last 25 years. Amongst different types of lung …

Abstract Overexpression of cyclooxygenase-2 (COX-2) is seen in a high percentage of
human colon tumors, lung adenocarcinomas and other cancers. Inhibition of this enzyme …

Abstract Hypoxia-inducible factors (HIFs), in particular HIF-1α, have been implicated in
tumor biology. However, HIF target genes in the esophageal tumor microenvironment …

Cyclooxygenase-2 (COX-2) overexpression is seen in many malignancies including lung
cancer. In non-small cell lung cancer (NSCLC), COX-2 is overexpressed in most …

Airway epithelial cancer cells produce increased amounts of the chemokine interleukin-8 (IL-
8), inducing pro-tumor responses. Multiple stimuli induce airway epithelial IL-8 production …