We previously reported that neutrophil elastase (NE) downregulates transforming growth
factor-β (TGF-β)-maintained tropoelastin mRNA levels in lung fibroblasts through …

Alveolar epithelial cells (AECs) may influence neighboring fibroblasts by the elaboration of
prostaglandin E2 (PGE2). This prostanoid can be synthesized via “constitutive” …

Evidence is accumulating to suggest that the inducible isoenzyme of cyclooxygenase (COX)-
2 is up-regulated in human cancers and epidemiological studies indicate that COX inhibitors …

Aberrant expression of COX-2 occurs in many types of malignancies including colon and
lung cancers, and is implicated in development and progression of cancer. The molecular …

In the present studies we found that incubation of human lung fibroblasts with transforming
growth factor-β1 (TGF-β1) potentiated the interleukin-1β (IL-1β) and/or tumor necrosis factor …

Background: Cyclooxygenase-2 (COX-2) over-expression and subsequent prostaglandin E2
(PGE2) production are frequently associated with human non-small-cell lung cancer …

The role of COX-2 expression and angiogenesis of lung cancer is yet to be delineated.
Eighty four non-small cell lung cancer (NSCLC) specimens were evaluated for COX-2 …

Lung cancer is the leading cause of cancer death in the United States. Although the low 5-
year survival rate (under 15%) has changed minimally in the last 25 years, new agents and …

Transforming growth factor (TGF)-α and its receptor, the epidermal growth factor receptor,
are induced after lung injury and are associated with remodeling in chronic pulmonary …

Purpose: Recurrent respiratory papillomas, caused by human papillomaviruses, are
premalignant tumors that overexpress the epidermal growth factor receptor (EGFR). The …