Purpose: Prostanoids are important mediators of pulmonary vaso-and bronchotone
regulation and strongly influence inflammatory reactivity. The product of cyclooxygenase …

Cyclooxygenase-2 (Cox2) may play a crucial role in lung carcinogenesis. In fact,
overexpression of Cox2 is common in non-small cell lung cancer (NSCLC) and seems to be …

Abstract Cyclooxygenase-2 (COX-2) is an enzyme involved in prostaglandin production in
pathologic states such as inflammatory disorders and cancer. The enzyme is often …

Cancers form more prostaglandins than the normal tissues from which they arise.
Cyclooxygenase-2 (prostaglandin H synthase-2, PGHS-2, EC 1.14. 99.1), an enzyme that …

We studied the effect of endogenous and exogenous prostaglandin E2 (PGE2), a metabolite
of arachidonic acid through the cyclooxygenase (COX) pathway, on interleukin (IL)-1 β …

Abstract Cyclooxygenase-2 (COX-2) is well established to play an important role in the
tumorigenesis of a variety of human cancers; however, the function of COX-2 in the …

Accumulating evidence suggests that overproduction of prostaglandin (PG) E2 attributable
to induction of cyclooxygenase-2 plays an important role in the development of lung …

Many studies have suggested a role for the hepatocyte growth factor (HGF)/c-Met pathway in
tumorigenesis. Some actions of HGF are believed to be mediated by cyclooxygenase-2 …

Many human cancers express elevated levels of cyclooxygenase-2 (COX-2), an enzyme
responsible for the biosynthesis of prostaglandins. Available clinical data establish the …

Increasing evidence has suggested that high expression level of cyclooxygenase-2 (Cox-2)
is associated with the malignancies of non–small cell lung cancer (NSCLC), leading to a …