Mitochondria have emerged as important targets for cisplatin in cancer therapy. Apart from
cisplatin, anticancer Pt complexes based on similar scaffolds have also been developed to …

In this work, we present the first study about the interactions of mitochondria-damaging Pt
(IV) prodrugs with cytochrome c. We synthesized a cisplatin-based Pt (IV) prodrug bearing a …

Cancer cells usually adapt metabolic phenotypes to chemotherapeutics. A defensive
strategy against this flexibility is to modulate signaling pathways relevant to cancer …

Mitochondria are potential therapeutic targets for anticancer drugs. A series of
mitochondrion-targeted monofunctional platinum complexes,[Pt (ortho-PPh3CH2Py)(NH3) …

The mitochondria are essential for tumorigenesis and have been regarded as important
targets in cancer chemotherapy. Herein, the mitochondria-targeted platinum (II) complexes …

Mitochondria-targeted therapy is an alternative strategy for cancer therapy and may
overcome the problems of metastasis and drug resistance that usually occur in conventional …

The mitochondrion is an important intracellular organelle for drug targeting due to its key
roles and functions in cellular proliferation and death. In the last few decades, several …

Mitochondria have recently emerged as novel targets for cancer therapy due to its important
roles in fundamental cellular function. Discovery of new chemotherapeutic agents that allow …

Mitophagy is a selective autophagic process that degrades dysfunctional mitochondria.
Monofunctional platinum (II) complexes are candidates for anticancer drugs with the …

Subcellular organelle‐specific reagents for simultaneous tumor targeting, imaging, and
treatment are of enormous interest in cancer therapy. Herein, we present a mitochondria …