Neuroimaging of hippocampal atrophy in early recognition of Alzheimer´ s disease–a critical appraisal after two decades of research

J Schröder, J Pantel - Psychiatry Research: Neuroimaging, 2016 - Elsevier
As a characteristic feature of Alzheimer´ s disease (AD) hippocampal atrophy (HA) can be
demonstrated in the majority of patients by using neuroimaging techniques in particular …

Is hippocampal atrophy on magnetic resonance imaging a marker for Alzheimer's disease?

JT O'Brien - International Journal of Geriatric Psychiatry, 1995 - psycnet.apa.org
Reviews recent magnetic resonance imaging (MRI) studies suggesting that temporal lobe
and, in particular, hippocampal atrophy may be a marker for Alzheimer's disease (AD). The …

Early diagnosis of Alzheimer's disease: contribution of structural neuroimaging

G Aël Chetelat, JC Baron - Neuroimage, 2003 - Elsevier
To accurately predict the development of Alzheimer's disease (AD) at its predementia stage
would be a major breakthrough from both therapeutic and research standpoints. In this …

Presymptomatic hippocampal atrophy in Alzheimer's disease: a longitudinal MRI study

NC Fox, EK Warrington, PA Freeborough… - Brain, 1996 - academic.oup.com
The hippocampal formation (HF) is known from pathological and MRI studies to be severely
atrophied in established Alzheimer's disease. However, it is unclear when the earliest …

Hippocampal atrophy correlates with the severity of cognitive decline

BB Yavuz, S Ariogul, M Cankurtaran… - International …, 2007 - cambridge.org
Background: The aim of this study is to compare the results of magnetic resonance (MR)
imaging, particularly the decline in hippocampal volume, of patients with Alzheimer's …

MRI of the hippocampus in Alzheimer's disease: sensitivity, specificity, and analysis of the incorrectly classified subjects

MP Laakso, H Soininen, K Partanen, M Lehtovirta… - Neurobiology of …, 1998 - Elsevier
In this study, magnetic resonance imaging (MRI) of the hippocampus for the diagnosis of
early Alzheimer's disease (AD) is evaluated. We measured hippocampal volumes and the …

Contribution of structural neuroimaging to the early diagnosis of Alzheimer's disease

MJ de Leon, A Convit, S DeSanti… - International …, 1997 - cambridge.org
There is compelling evidence for the early involvement of the hippocampal formation in the
natural history of Alzheimer's disease (AD). The evidence comes from recent …

Distinct subtypes of Alzheimer's disease based on patterns of brain atrophy: longitudinal trajectories and clinical applications

D Ferreira, C Verhagen, JA Hernández-Cabrera… - Scientific reports, 2017 - nature.com
Atrophy patterns on MRI can reliably predict three neuropathological subtypes of
Alzheimer's disease (AD): typical, limbic-predominant, or hippocampal-sparing. A method to …

Antemortem MRI findings correlate with hippocampal neuropathology in typical aging and dementia

CR Jack Jr, DW Dickson, JE Parisi, YC Xu, RH Cha… - Neurology, 2002 - AAN Enterprises
Objectives: To assess the diagnostic specificity of MRI-defined hippocampal atrophy for AD
among individuals with a variety of pathologically confirmed conditions associated with …

Hippocampal atrophy in early Alzheimer's disease: anatomic specificity and validation

A Convit, MJ De Leon, J Golomb, AE George… - Psychiatric …, 1993 - Springer
We evaluated three groups of elderly individuals who were carefully screened to rule out
clinically significant diseases that could affect cognition. They were matched for age and …