The antifungal pipeline: a reality check
JR Perfect - Nature reviews Drug discovery, 2017 - nature.com
Invasive fungal infections continue to appear in record numbers as the
immunocompromised population of the world increases, owing partially to the increased …
immunocompromised population of the world increases, owing partially to the increased …
Potential targets for the development of new antifungal drugs
H Su, L Han, X Huang - The journal of antibiotics, 2018 - nature.com
In recent years, incidences of invasive fungal infections have greatly increased, especially in
immunosuppressed patients, but most today's antifungal drugs are not completely effective …
immunosuppressed patients, but most today's antifungal drugs are not completely effective …
How urgent is the need for new antifungals?
AG Stewart, DL Paterson - Expert Opinion on Pharmacotherapy, 2021 - Taylor & Francis
Introduction: Invasive fungal infection carries a high morbidity, mortality and economic cost.
In recent times, a rising incidence of fungal infection and antifungal resistance is occurring …
In recent times, a rising incidence of fungal infection and antifungal resistance is occurring …
[图书][B] Antifungals: from genomics to resistance and the development of novel agents
AT Coste, P Vandeputte - 2015 - univ-angers.hal.science
From the publisher's website: Infections caused by pathogenic fungi are a significant global
problem: a situation exacerbated by the limited availability of good antifungal options. Being …
problem: a situation exacerbated by the limited availability of good antifungal options. Being …
Tackling the emerging threat of antifungal resistance to human health
Invasive fungal infections pose an important threat to public health and are an under-
recognized component of antimicrobial resistance, an emerging crisis worldwide. Across a …
recognized component of antimicrobial resistance, an emerging crisis worldwide. Across a …
[HTML][HTML] Antifungal pipeline
TP McCarty, PG Pappas - Frontiers in cellular and infection …, 2021 - frontiersin.org
In many ways, fungal diseases are forgotten or neglected. Given the significantly lower
frequency compared to similar bacterial etiologies across the spectrum of infectious …
frequency compared to similar bacterial etiologies across the spectrum of infectious …
Emerging new targets for the treatment of resistant fungal infections
N Liu, J Tu, G Dong, Y Wang… - Journal of medicinal …, 2018 - ACS Publications
With the increasing morbidity and mortality of invasive fungal infections and the emergence
of severe antifungal drug resistance, new drug targets and novel antifungal agents are …
of severe antifungal drug resistance, new drug targets and novel antifungal agents are …
[HTML][HTML] Fungal infections: Pathogenesis, antifungals and alternate treatment approaches
GKK Reddy, AR Padmavathi… - Current Research in …, 2022 - Elsevier
Increasing incidence of fungal infections of recent times requires immediate intervention.
Fungal infections are seldom construed at initial stages that intensify the severity of …
Fungal infections are seldom construed at initial stages that intensify the severity of …
Drug resistance and tolerance in fungi
J Berman, DJ Krysan - Nature Reviews Microbiology, 2020 - nature.com
Systemic fungal infections pose a serious clinical problem. Treatment options are limited,
and antifungal drug resistance is increasing. In addition, a substantial proportion of patients …
and antifungal drug resistance is increasing. In addition, a substantial proportion of patients …
Antifungal drugs: the current armamentarium and development of new agents
Invasive fungal infections are becoming an increasingly important cause of human mortality
and morbidity, particularly for immunocompromised populations. The fungal pathogens …
and morbidity, particularly for immunocompromised populations. The fungal pathogens …