Tumor suppressor p53 protein is a new target for the metastasis-associated Mts1/S100A4 protein: functional consequences of their interaction

M Grigorian, S Andresen, E Tulchinsky… - Journal of Biological …, 2001 - ASBMB
A physical and functional interaction between the Ca 2+-binding protein Mts1 (S100A4) and
the tumor suppressor p53 protein is shown here for the first time. We demonstrate that Mts1 …

Inhibition of p53 transcriptional activity by the S100B calcium-binding protein

J Lin, M Blake, C Tang, D Zimmer, RR Rustandi… - Journal of Biological …, 2001 - ASBMB
The levels of S100 Ca 2+-binding proteins correlate with the progression of certain tumors,
but their role, if any, in carcinogenesis is still poorly understood. S100B protein associates …

The calcium-binding protein S100A2 interacts with p53 and modulates its transcriptional activity

A Mueller, BW Schäfer, S Ferrari, M Weibel… - Journal of Biological …, 2005 - ASBMB
Head and neck squamous cell carcinoma express high levels of the EF-hand calcium-
binding protein S100A2 in contrast to other tumorigenic tissues and cell lines where the …

[HTML][HTML] Recognition of the tumor suppressor protein p53 and other protein targets by the calcium-binding protein S100B

PT Wilder, J Lin, CL Bair, TH Charpentier… - … et Biophysica Acta (BBA …, 2006 - Elsevier
S100B is an EF-hand containing calcium-binding protein of the S100 protein family that
exerts its biological effect by binding and affecting various target proteins. A consensus …

S100A4 interacts with p53 in the nucleus and promotes p53 degradation

LM Orre, E Panizza, VO Kaminskyy, E Vernet… - Oncogene, 2013 - nature.com
S100A4 is a small calcium-binding protein that is commonly overexpressed in a range of
different tumor types, and it is widely accepted that S100A4 has an important role in the …

Effect of mts1 (S100A4) expression on the progression of human breast cancer cells

M Grigorian, N Ambartsumian… - … journal of cancer, 1996 - Wiley Online Library
Abstract The mts1 (S100A4) gene, encoding a Ca2+‐binding protein of the S‐100 subfamily,
is involved in the control of tumor metastasis in some murine tumor cell lines. To further …

Inhibiting S100B restores p53 levels in primary malignant melanoma cancer cells

J Lin, Q Yang, Z Yan, J Markowitz, PT Wilder… - Journal of Biological …, 2004 - ASBMB
S100 calcium-binding proteins such as S100B are elevated in primary malignant melanoma
and are used as markers for this and numerous other cancers. Wild-type p53 protein levels …

Solution structure of human Mts1 (S100A4) as determined by NMR spectroscopy

KM Vallely, RR Rustandi, KC Ellis, O Varlamova… - Biochemistry, 2002 - ACS Publications
Mts1 is a member of the S100 family of Ca2+-binding proteins and is implicated in promoting
tumor progression and metastasis. To better understand the structure− function relationships …

Metastasis-associated Mts1 (S100A4) protein modulates protein kinase C phosphorylation of the heavy chain of nonmuscle myosin

M Kriajevska, S Tarabykina, I Bronstein… - Journal of Biological …, 1998 - ASBMB
Mts1 protein (S100A4 according to a new classification) has been implicated in the
formation of the metastatic phenotype via regulation of cell motility and invasiveness …

Modulation of mts1 expression in mouse and human normal and tumor cells

M Grigorian, E Tulchinsky, O Burrone… - …, 1994 - Wiley Online Library
The mts1 gene, encoding small Ca2+‐binding protein of the S100‐family, is considered as a
gene whose activity correlates with the manifestation of a metastatic phenotype of tumor …