The effects of age on functional connectivity (FC) of intrinsic connectivity networks (ICNs)
have largely been derived from cross-sectional studies. Far less is known about longitudinal …

Older adults typically show weaker functional connectivity (FC) within brain networks
compared with young adults, but stronger functional connections between networks. Our …

Recent work suggests that the default mode network (DMN) includes two core regions, the
ventromedial prefrontal cortex and posterior cingulate cortex (PCC), and several unique …

Intrinsic functional connectivity MRI has become a widely used tool for measuring integrity in
large-scale cortical networks. This study examined multiple cortical networks using Template …

Neuroimaging studies have documented that aging can disrupt certain higher cognitive
systems such as the default mode network (DMN), the salience network and the central …

Background: Vast increases in life expectancy over the last century have led to shifts in
population demographics and the emergence of a largely aged population, globally. This …

Healthy aging has been associated with a decrease in functional network specialization.
Importantly, variability of alterations of functional connectivity is especially high across older …

The default mode network (DMN) supports memory functioning and may be sensitive to
preclinical Alzheimer's pathology. Little is known, however, about the longitudinal trajectory …

Aging leads to global changes in brain structure and cognitive performance, with
reorganization of functional brain networks. Importantly, these age-related changes show …

Aging is associated with disruptions in the resting-state functional architecture of the brain.
Previous studies have primarily focused on age-related declines in the default mode …