Nerve transfer for restoration of lower motor neuron–lesioned bladder and urethra function: establishment of a canine model and interim pilot study results

E Tiwari, DM Salvadeo, AS Braverman… - … of Neurosurgery: Spine, 2019 - thejns.org
OBJECTIVE Previous patient surveys have shown that patients with spinal cord or cauda
equina injuries prioritize recovery of bladder function. The authors sought to determine if …

Nerve transfer for restoration of lower motor neuron-lesioned bladder, urethral and anal sphincter function. Part 4: Effectiveness of the motor reinnervation

E Tiwari, DS Porreca, AS Braverman… - American Journal …, 2024 - journals.physiology.org
In pilot work, we showed that somatic nerve transfers can restore motor function in long-term
decentralized dogs. We continue to explore the effectiveness of motor reinnervation in 30 …

Nerve transfer for restoration of lower motor neuron-lesioned bladder function. Part 2: Correlation between histological changes and nerve evoked contractions

MF Barbe, CL Testa, GE Cruz… - American Journal …, 2021 - journals.physiology.org
We determined the effect of pelvic organ decentralization and reinnervation 1 yr later on
urinary bladder histology and function. Nineteen canines underwent decentralization by …

Functional reinnervation of the canine bladder after spinal root transection and genitofemoral nerve transfer at one and three months after denervation

MR Ruggieri Sr, AS Braverman, L D'Andrea… - Journal of …, 2008 - liebertpub.com
In the immediate management of patients with spinal cord injury (SCI), patients are typically
observed for a period of time to determine whether voluntary control of bladder function …

Bladder reinnervation by somatic nerve transfer to pelvic nerve vesical branches does not reinnervate the urethra

MF Barbe, AS Braverman, DM Salvadeo… - Neurourology and …, 2020 - Wiley Online Library
Aims We sought to determine whether somatic lumbar nerve transfer to the pelvic nerve's
anterior vesical branch after sacral decentralization for detrusor muscle reinnervation also …

Innervation of parasympathetic postganglionic neurons and bladder detrusor muscle directly after sacral root transection and repair using nerve transfer

MF Barbe, MR Ruggieri Sr - Neurourology and urodynamics, 2011 - Wiley Online Library
Aims: This is a continuation of studies examining the effectiveness of root repairs and nerve
transfers for bladder reinnervation. Our previous retrograde fluorogold tracing studies from …

Anatomical feasibility of performing intercostal and ilioinguinal nerve to pelvic nerve transfer: a possible technique to restore lower urinary tract innervation

JM Brown, MF Barbe, ME Albo, HH Lai… - Journal of Neurosurgery …, 2012 - thejns.org
Object Nerve transfers are effective for restoring control to paralyzed somatic muscle groups
and, recently, even to denervated detrusor muscle in a canine model. A pilot project was …

Functional reinnervation of the canine bladder after spinal root transection and immediate somatic nerve transfer

MR Ruggieri Sr, AS Braverman, L D'Andrea… - Journal of …, 2008 - liebertpub.com
This study was performed to determine whether nerve transfer immediately after spinal root
transection would lead to bladder reinnervation in a canine model. In one animal, the left …

Determining integrity of bladder innervation and smooth muscle function 1 year after lower spinal root transection in canines

DM Salvadeo, E Tiwari, N Frara… - Neurourology and …, 2018 - Wiley Online Library
Aims To assess bladder smooth muscle function and innervation after long‐term lower
spinal root transection in canines. Methods Thirteen female mixed‐breed hound dogs …

Neural reconstruction methods of restoring bladder function

SM Gomez-Amaya, MF Barbe, WC De Groat… - Nature Reviews …, 2015 - nature.com
During the past century, diverse studies have focused on the development of surgical
strategies to restore function of a decentralized bladder after spinal cord or spinal root injury …