Previous studies have shown that static equilibrium compression of cartilage tissue in vivo
and in vitro decreases chondrocyte synthesis of aggrecan molecules. In order to identify …

In this study, we investigated the depth‐dependent metabolic and structural responses of
adult articular cartilage to large‐strain, static, unconfined compression. Changes in cell …

The goal of this study was to examine the effects of mechanical compression on chondrocyte
biosynthesis of extracellular matrix (ECM) components during culture in a new alginate disk …

The effects of hypotonic (180 mOsm) and hypertonic (580 mOsm) medium loading on
chondrocyte aggrecan gene expression in 2D monolayer and 3D hydrogel culture (agarose …

The main function of articular cartilage is to transmit load. The objective of this study was to
describe the deformation of chondrocytes under static loading and its relation to collagen …

We have used new techniques of cell-length scale quantitative autoradiography to assess
matrix synthesis, deposition, and deformation around individual chondrocytes in …

Although it is well known that the metabolism of chondrocytes can be altered by the
application of mechanical strain, it is unclear whether chondrocytes from the superficial and …

The differential effects of static compression and recovery from compression on biosynthesis
and biosynthetic pathways of aggrecan, link protein, and hyaluronan were assessed. During …

Mechanical loading of articular cartilage can produce catabolic and anabolic changes in
tissue metabolism. Most previous studies in this area have focussed on aggrecan. Little …

OBJECTIVE: The effects of mechanical deformation of intact cartilage tissue on chondrocyte
biosynthesis in situ have been well documented, but the mechanotransduction pathways …