[HTML][HTML] Insulin-induced phosphorylation of the 46-and 52-kDa Shc proteins.
GJ Pronk, J McGlade, G Pelicci, T Pawson… - Journal of Biological …, 1993 - Elsevier
The products of the shc gene appear to be substrates for activated oncogenic tyrosine
kinases, such as v-Src and v-Fps and activated tyrosine kinase receptors like the epidermal …
kinases, such as v-Src and v-Fps and activated tyrosine kinase receptors like the epidermal …
Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1, and epidermal growth factor.
T Sasaoka, DW Rose, BH Jhun, AR Saltiel… - Journal of Biological …, 1994 - ASBMB
Shc proteins contain a single SH2 domain, lack catalytic activity, and are substrates for
activated receptors for insulin, insulin-like growth factor-1 (IGF-1), and epidermal growth …
activated receptors for insulin, insulin-like growth factor-1 (IGF-1), and epidermal growth …
[HTML][HTML] Shc Isoform-specific Tyrosine Phosphorylation by the Insulin and Epidermal Growth Factor Receptors (∗)
S Okada, K Yamauchi, JE Pessin - Journal of Biological Chemistry, 1995 - ASBMB
Insulin stimulation of Chinese hamster ovary cells expressing the human insulin and
epidermal growth factor (EGF) receptors (CHO/IR/ER) resulted in the tyrosine …
epidermal growth factor (EGF) receptors (CHO/IR/ER) resulted in the tyrosine …
A region in Shc distinct from the SH2 domain can bind tyrosine-phosphorylated growth factor receptors.
P Blaikie, D Immanuel, J Wu, N Li, V Yajnik… - Journal of Biological …, 1994 - Elsevier
Shc is a ubiquitously expressed Src homology 2 (SH2) domain protein that can transform
fibroblasts and differentiate PC12 cells in a Ras-dependent fashion. Shc binds a variety of …
fibroblasts and differentiate PC12 cells in a Ras-dependent fashion. Shc binds a variety of …
Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases.
J Mcglade, A Cheng, G Pelicci… - Proceedings of the …, 1992 - National Acad Sciences
The mammalian shc gene encodes two overlapping proteins of 46 and 52 kDa, each with a
C-terminal Src homology 2 (SH2) domain and an N-terminal glycine/proline-rich sequence …
C-terminal Src homology 2 (SH2) domain and an N-terminal glycine/proline-rich sequence …
Identification of Shc as a substrate of the insulin receptor kinase distinct from the GAP-associated 62-kDa tyrosine phosphoprotein
KS Kovacina, RA Roth - Biochemical and biophysical research …, 1993 - Elsevier
Insulin stimulated tyrosine phosphorylation of SHC, a SH2 containing protein, was
demonstrated in Chinese hamster ovary cellsoverexpressing the insulin receptor by …
demonstrated in Chinese hamster ovary cellsoverexpressing the insulin receptor by …
[HTML][HTML] The 66-kDa Shc isoform is a negative regulator of the epidermal growth factor-stimulated mitogen-activated protein kinase pathway
S Okada, AW Kao, BP Ceresa, P Blaikie… - Journal of Biological …, 1997 - ASBMB
In addition to tyrosine phosphorylation of the 66-, 52-, and 46-kDa Shc isoforms, epidermal
growth factor (EGF) treatment of Chinese hamster ovary cells expressing the human EGF …
growth factor (EGF) treatment of Chinese hamster ovary cells expressing the human EGF …
Constitutive phosphorylation of Shc proteins in human tumors.
G Pelicci, L Lanfrancone, AE Salcini, A Romano… - Oncogene, 1995 - europepmc.org
The Shc gene encodes three overlapping proteins which all contain a carboxy-terminal SH2
domain. Shc proteins are ubiquitously expressed and are downstream targets and effectors …
domain. Shc proteins are ubiquitously expressed and are downstream targets and effectors …
Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain
TA Gustafson, W He, A Craparo… - … and cellular biology, 1995 - Am Soc Microbiol
The SHC proteins have been implicated in insulin receptor (IR) signaling. In this study, we
used the sensitive two-hybrid assay of protein-protein interaction to demonstrate that SHC …
used the sensitive two-hybrid assay of protein-protein interaction to demonstrate that SHC …
A family of Shc related proteins with conserved PTB, CH1 and SH2 regions.
G Pelicci, L Dente, A De Giuseppe, B Verducci-Galletti… - Oncogene, 1996 - europepmc.org
Shc proteins are targets of activated tyrosine kinases and have been implicated in the
transmission of activation signals to Ras. Upon phosphorylation, Shc proteins form stable …
transmission of activation signals to Ras. Upon phosphorylation, Shc proteins form stable …