Apoptotic elimination of pathogenic T cells is considered to be one of regulatory
mechanisms in multiple sclerosis (MS). To explore the potential relationship between Fas …

Introduction Multiple sclerosis (MS) is a chronic autoimmune disorder that affects the central
nervous system and compromises the health and well-being of millions of people worldwide …

Background There is accumulating evidence from immunological, pathological and
therapeutic studies that B cells are key components in the pathophysiology of multiple …

In the central nervous system of patients with multiple sclerosis, B cell aggregates populate
the meninges, raising the central question as to whether these structures relate to the B cell …

In multiple sclerosis (MS) pathogenic B cells likely act on both sides of the blood-brain
barrier (BBB). However, it is unclear whether antigen-experienced B cells are shared …

The contribution of B cells and their products to the pathogenesis of MS has long been
debated. The presence of B cells, plasma cells and excess immunoglobulins in MS lesions …

A dual role of B cells in experimental autoimmune encephalomyelitis (EAE), the animal
model of the human autoimmune disease multiple sclerosis (MS), has been established. In …

Multiple sclerosis (MS) is characterized by lesions with inflammatory infiltration,
demyelination and axonal damage in the CNS white matter that correlates with the extent of …

We investigated the sensitivity to cell death of peripheral blood mononuclear cells (PBMCs)
from patients with multiple sclerosis (MS). PBMCs from MS patients, following PHA …

Abstract Interleukin 4 (IL-4)-and interferon γ (IFNγ)-secreting peripheral blood cells were
enumerated by immunospot assay in 13 multiple sclerosis (MS) patients during …