Over the last two decades, numerous attempts have been made to develop 11C-and 18F-
labeled radiotracers in order to study glucocorticoid receptor (GR)-mediated abnormalities of …

Corticosteroids regulate a variety of essential physiological functions, such as mineral
balance and stress. The great interest in these steroids, especially the glucocorticoids, stems …

The radiosynthesis and the radiopharmacological evaluation of pyrazolo steroid 2′-(4-
fluorophenyl)-21-[18F] fluoro-20-oxo-11β, 17α-dihydroxy-pregn-4-eno [3, 2-c] pyrazole [18F] …

The radiosynthesis of [N-methyl-11C] Org 34850 as a potential brain glucocorticoid receptor
(GR)-binding radiotracer is described. The radiosynthesis was accomplished via N …

We have prepared eight fluorine-substituted corticosteroids representing ligands selective
for Type I and Type II corticosteroid receptor subtypes as potential imaging agents for …

The rapid and continual development of a number of radiopharmaceuticals targeting
different receptor, enzyme and small molecule systems has fostered Positron Emission …

We have synthesized several halogenated steroids as potential glucocorticoid receptor
mediated imaging agents. These compounds are analogs of aryl-pyrazolo steroids, similar …

For the synthesis of [18F] Fluoro-Org 6141 via a nucleophilic substitution reaction with 18F−,
the tosyl group was chosen as the leaving group because of its stability and excellent …

Abstract 11, 17β-Dihydroxy-6-methyl-17α-(3-[18 F] fluoro-prop-1-ynyl) androsta-1, 4, 6-trien-
3-one ([18 F] RU 52461), an 18 F-analog of RU 28362, was synthesized by bromide …

Ligands for the glucocorticoid receptor labeled with high-energy isotopes are highly desired
for their potential applications in nuclear medical studies of the brain where the …