Osteoarthritis (OA) is a most common multifactorial degenerative joint disease in elderly
individuals. OA is affecting severely the quality of life of patients, while the causes of OA are …

Osteoarthritis (OA) is one of the most common degenerative joint diseases in aging
population. Obesity is an important risk factor for initiation and progression of OA. It is …

Osteoarthritis is the most prevalent form of aging-related joint diseases, and its etiology is
still not fully understood. Obesity has been recognized as one of the most significant and …

Along with its capacity to store energy, the white adipose tissue is a source of cytokines,
called “adipocytokines” or “adipokines”, acting by paracrine, autocrine and systemic …

Inflammatory rheumatic diseases (IRD) are complex disorders characterized by chronic
inflammation of the joints and related skeletal structures. The most common forms of IRD are …

Secretion from adipose tissue of adipokines or adipocytokines, comprising of bioactive
peptides or proteins, immune molecules and inflammatory mediators, exert critical roles in …

Abstract Purpose of the Review Osteoarthritis (OA) is an aging-associated and injury-
induced joint disease characterized by cartilage degradation, bone sclerosis, and persistent …

We performed a systematic literature review to summarize the underlying pathogenic
mechanisms by which adipokines influence rheumatological diseases and the resulting …

Adipokines are proteins produced by white adipose tissue, which is an active secretory
organ. Regulation of immune and inflammatory responses is among the multiple …

Rheumatoid arthritis affects millions of people worldwide and is considered a chronic
multisystem disease whose causes are unknown. In general, the main objective of …