OBJECTIVE: Recently the use of free fetal deoxyribonucleic acid (DNA) in maternal plasma
and serum has been applicable for noninvasive prenatal genetic diagnosis. In this study, we …

Objectives To validate the use of Real Time PCR, a widely used technique that can detect
very low levels of Y chromosomal sequence, and to assess the use of a highly sensitive …

Objective This study reviews our clinical experience of non‐invasive techniques for early sex
determination. It assesses the effectiveness of these techniques at reducing invasive …

Objective To assess the viability of the early diagnosis of fetal gender in maternal plasma
before 7 weeks of pregnancy by real‐time polymerase chain reaction (real‐time PCR) …

Background The knowledge of the individual genetic “status” in the prenatal era is
particularly relevant in the case of positive family history for genetic diseases, in advanced …

Analysis of fetal DNA in maternal plasma has recently been introduced as a new method for
noninvasive prenatal diagnosis. In the majority of cases, the Y chromosome–specific …

Objective. The detection of paternally inherited sequences in maternal plasma, such as the
SRY gene for fetal sexing or RHD for fetal blood group genotyping, is becoming part of daily …

Non-invasive prenatal determination of fetal sex offers a promising alternative to invasive
diagnosis of X-linked diseases and fetal disorders of ambiguous genitalia (1–4). Using free …

Context Noninvasive prenatal determination of fetal sex using cell-free fetal DNA provides
an alternative to invasive techniques for some heritable disorders. In some countries this …

OBJECTIVE: To determine first-trimester fetal sex by isolating free fetal DNA from maternal
plasma. METHODS: The index case was a pregnant woman who previously delivered a girl …