Deamination of nucleobases in DNA and RNA results in the formation of xanthine (X),
hypoxanthine (I), oxanine, and uracil, all of which are miscoding and mutagenic in DNA and …

Nitric oxide (NO•) reacts with guanine in DNA and RNA to produce xanthine (X) as a major
product. Despite its potential importance in NO•-mediated mutagenesis, the biochemical …

Deoxycytidine, deoxyadenosine and deoxyguanosine undergo spontaneous deamination to
form deoxyuridine, deoxyinosine and deoxyxanthosine, respectively. In this manuscript, we …

Deoxyuridine can become resident in the DNA of prokaryotic and eukaryotic cells via two
general mechanisms—deamination of cytosine to uracil, and nucleotide pool changes that …

The deamination of adenine residues in DNA generates hypoxanthine, which is mutagenic
since it gives rise to an AT to GC transition. Hypoxanthine is removed by hypoxanthine DNA …

The biosynthesis of purines and pyrimidines is stringently regulated and coordinated by
feedback mechanisms that ensure their production in quantities and at times appropriate to …

Purines and pyrimidines, regarded for a long time only as building blocks for nucleic acid
synthesis and intermediates in the transfer of metabolic energy, gained increasing attention …

Deamination of DNA bases can occur spontaneously, generating highly mutagenic lesions
such as uracil, hypoxanthine, and xanthine. When cells are under oxidative stress that is …

Purine nucleotides are critically important for the normal functioning of cells due to their
myriad of activities. It is important for cells to maintain a balance in the pool sizes of the …

A DNA glycosylase that releases free hypoxanthine by selective cleavage of dIMP residues
in polydeoxynucleotides and DNA containing this nonconventional nucleotide is present in …