Electrical remodeling in atrial fibrillation

D Dobrev - Herz, 2006 - search.proquest.com
Electrical remodeling refers to any change in electrical function that promotes atrial
fibrillation (AF). A key advance in understanding the mechanisms of AF has been the …

Molecular basis of electrical remodeling in atrial fibrillation

DR Van Wagoner, JM Nerbonne - Journal of molecular and cellular …, 2000 - Elsevier
DR Van Wagoner and JM Nerbonne. Molecular Basis of Electrical Remodeling in Atrial
Fibrillation. Journal of Molecular and Cellular Cardiology (2000) 32, 1101–1117. Atrial …

Molecular mechanisms of remodeling in human atrial fibrillation

BJJM Brundel, RH Henning… - Cardiovascular …, 2002 - academic.oup.com
An important acknowledgement of the last several years is that atrial fibrillation (AF) modifies
the electrical properties of the atrium in a way that promotes its occurrence and …

Atrial electrophysiological remodeling and fibrillation in heart failure

SV Pandit, AJ Workman - Clinical Medicine Insights …, 2016 - journals.sagepub.com
Heart failure (HF) causes complex, chronic changes in atrial structure and function, which
can cause substantial electrophysiological remodeling and predispose the individual to …

Calcium handling abnormalities in atrial fibrillation as a target for innovative therapeutics

D Dobrev, S Nattel - Journal of cardiovascular pharmacology, 2008 - journals.lww.com
Atrial electrical and structural alterations (remodeling) have emerged as key elements in the
development of the atrial fibrillation (AF) substrate. Evidence points to abnormalities in …

Cellular and molecular electrophysiology of atrial fibrillation initiation, maintenance, and progression

J Heijman, N Voigt, S Nattel, D Dobrev - Circulation research, 2014 - Am Heart Assoc
Atrial fibrillation (AF) is the most common clinically relevant arrhythmia and is associated
with increased morbidity and mortality. The incidence of AF is expected to continue to rise …

Remodeling of cardiomyocyte ion channels in human atrial fibrillation

D Dobrev, U Ravens - Basic research in cardiology, 2003 - Springer
This review is focused on electrical adaptational processes in patients with chronic AF.
Cellular electrical remodeling includes shortening of action potential duration and effective …

Basic mechanisms of atrial fibrillation—very new insights into very old ideas

S Nattel, D Li, L Yue - Annual Review of Physiology, 2000 - annualreviews.org
▪ Abstract Atrial fibrillation (AF) was recognized and studied extensively in the early twentieth
century, but many fundamental aspects of the arrhythmia were poorly understood until quite …

[HTML][HTML] Atrial fibrillation: mechanisms, therapeutics, and future directions

J Pellman, F Sheikh - Comprehensive Physiology, 2015 - ncbi.nlm.nih.gov
Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia, affecting 1% to 2% of the
general population. It is characterized by rapid and disorganized atrial activation leading to …

Molecular insights in atrial fibrillation pathogenesis and therapeutics: a narrative review

KA Papathanasiou, SG Giotaki, DA Vrachatis, G Siasos… - Diagnostics, 2021 - mdpi.com
The prevalence of atrial fibrillation (AF) is bound to increase globally in the following years,
affecting the quality of life of millions of people, increasing mortality and morbidity, and …