Atrial Ca2+ signaling in atrial fibrillation as an antiarrhythmic drug target
D Dobrev - Naunyn-Schmiedeberg's archives of pharmacology, 2010 - Springer
Atrial fibrillation (AF) is the most frequent arrhythmia and is associated with increased
morbidity and mortality. Current drugs for AF treatment have moderate efficacy and increase …
morbidity and mortality. Current drugs for AF treatment have moderate efficacy and increase …
Electrical, contractile and structural remodeling during atrial fibrillation
M Allessie, J Ausma, U Schotten - Cardiovascular research, 2002 - academic.oup.com
The natural history of atrial fibrillation (AF) is characterized by a gradual worsening with time.
The recent finding that AF itself produces changes in atrial function and structure has …
The recent finding that AF itself produces changes in atrial function and structure has …
[HTML][HTML] Atrial remodeling and atrial fibrillation in acquired forms of cardiovascular disease
Atrial fibrillation (AF) is prevalent in common conditions and acquired forms of heart disease,
including diabetes mellitus (DM), hypertension, cardiac hypertrophy, and heart failure. AF is …
including diabetes mellitus (DM), hypertension, cardiac hypertrophy, and heart failure. AF is …
Structural and functional remodeling of the left atrium: clinical and therapeutic implications for atrial fibrillation
G Casaclang-Verzosa, BJ Gersh, TSM Tsang - Journal of the American …, 2008 - jacc.org
Left atrial (LA) structural and functional remodeling reflects a spectrum of pathophysiological
changes that have occurred in response to specific stressors. These changes include …
changes that have occurred in response to specific stressors. These changes include …
Aged atria: electrical remodeling conducive to atrial fibrillation
W Dun, PA Boyden - Journal of interventional cardiac electrophysiology, 2009 - Springer
The incidence of atrial fibrillation (AF) increases with age. Alterations in structure and
function of atrial ion channels associated with aging provide the substrate for AF. In this …
function of atrial ion channels associated with aging provide the substrate for AF. In this …
[HTML][HTML] Atrial remodeling and atrial fibrillation: mechanistic interactions and clinical implications
B Al Ghamdi, W Hassan - Journal of Atrial Fibrillation, 2009 - ncbi.nlm.nih.gov
Atrial fibrillation (AF) is the most common arrhythmia in clinical practice. The prevalence of
AF increases dramatically with age and is seen in as high as 9% of individuals by the age of …
AF increases dramatically with age and is seen in as high as 9% of individuals by the age of …
L-Type Ca2+ Current Downregulation in Chronic Human Atrial Fibrillation Is Associated With Increased Activity of Protein Phosphatases
T Christ, P Boknik, S Wohrl, E Wettwer, EM Graf… - Circulation, 2004 - Am Heart Assoc
Background—Although downregulation of L-type Ca2+ current (I Ca, L) in chronic atrial
fibrillation (AF) is an important determinant of electrical remodeling, the molecular …
fibrillation (AF) is an important determinant of electrical remodeling, the molecular …
Pro‐arrhythmogenic effects of atrial fibrillation‐induced electrical remodelling: insights from the three‐dimensional virtual human atria
Key points• Previous studies have shown that atrial electrical properties are altered
(remodelled) by atrial fibrillation (AF) and that the recurrence of AF is high following …
(remodelled) by atrial fibrillation (AF) and that the recurrence of AF is high following …
Atrial remodeling: new pathophysiological mechanism of atrial fibrillation
Y Xu, D Sharma, G Li, Y Liu - Medical hypotheses, 2013 - Elsevier
Atrial fibrillation (AF), the most common sustained arrhythmia associated with substantial
cardiovascular morbidity and mortality with stroke being the most critical complication. Most …
cardiovascular morbidity and mortality with stroke being the most critical complication. Most …
Computational models of atrial cellular electrophysiology and calcium handling, and their role in atrial fibrillation
The complexity of the heart makes an intuitive understanding of the relative contribution of
ion channels, transporters and signalling pathways to cardiac electrophysiology …
ion channels, transporters and signalling pathways to cardiac electrophysiology …