Atrial fibrillation is a complex arrhythmia with multiple possible mechanisms. A lot of
experimental and clinical studies have shed light on the pathophysiological mechanisms of …

Chronic atrial fibrillation (AF) is a complex disease with underlying changes in
electrophysiology, calcium signaling and the structure of atrial myocytes. How these …

Despite considerable basic research into the mechanisms of atrial fibrillation (AF), not much
progress has been made in the prognosis of patients with AF. With the exception of …

The complexity of the heart makes an intuitive understanding of the relative contribution of
ion channels, transporters and signalling pathways to cardiac electrophysiology …

Identifying upstream strategies targeting molecular pathways that are common to fibrosis
and electrical remodeling leading to atrial fibrillation perpetuation is highly desirable. This …

Atrial fibrillation (AF) is the most frequently encountered clinical arrhythmia and is associated
with increased morbidity and mortality. Ectopic activity and reentry are considered major …

Atrial fibrillation (AF) is commonly associated with heart failure. A bidirectional relationship
exists between the two—AF exacerbates heart failure causing a significant increase in heart …

Compensatory changes in ion transport mechanisms occur in response to a variety of
cardiac disease processes. Recent work has demonstrated that these adaptive responses …

Atrial fibrillation (AF) is the most common type of cardiac arrhythmia, affecting more than 33
million people worldwide. Despite important advances in therapy, AF's incidence remains …

The rapid atrial rate during atrial fibrillation (AF) decreases the ionic current density of
transient outward K+ current, L-type Ca2+ current, and Na+ current, thereby altering cardiac …