Recent insights into the role of the autonomic nervous system in the creation of substrate for atrial fibrillation: implications for therapies targeting the atrial autonomic …

R Arora - Circulation: Arrhythmia and Electrophysiology, 2012 - Am Heart Assoc
In this review, we discuss recent developments in our understanding of the role of the
autonomic nervous system in creating atrial fibrillation (AF) substrate and on how these …

Cellular and molecular mechanisms of atrial arrhythmogenesis in patients with paroxysmal atrial fibrillation

N Voigt, J Heijman, Q Wang, DY Chiang, N Li… - Circulation, 2014 - Am Heart Assoc
Background—Electrical, structural, and Ca2+-handling remodeling contribute to the
perpetuation/progression of atrial fibrillation (AF). Recent evidence has suggested a role for …

Arrhythmogenic ion-channel remodeling in the heart: heart failure, myocardial infarction, and atrial fibrillation

S Nattel, A Maguy, S Le Bouter… - Physiological …, 2007 - journals.physiology.org
Rhythmic and effective cardiac contraction depends on appropriately timed generation and
spread of cardiac electrical activity. The basic cellular unit of such activity is the action …

Antiarrhythmic therapy in atrial fibrillation

U Ravens - Pharmacology & therapeutics, 2010 - Elsevier
Currently available antiarrhythmic drugs for the management of AF are not sufficiently
effective and are burdened with cardiac and extracardiac side effects that may offset their …

[HTML][HTML] Cardiac transmembrane ion channels and action potentials: cellular physiology and arrhythmogenic behavior

V András, J Tomek, N Nagy, L Virág… - Physiological …, 2021 - journals.physiology.org
Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …

[HTML][HTML] Remodeling in persistent atrial fibrillation: pathophysiology and therapeutic targets—a systematic review

A Roka, I Burright - Physiologia, 2023 - mdpi.com
Atrial fibrillation (AF) is characterized by disorganized rapid atrial electrical activity, which
leads to impaired atrial function, adverse hemodynamic effects, and increased …

Distinct patterns of atrial electrical and structural remodeling in angiotensin II mediated atrial fibrillation

HJ Jansen, M Mackasey, M Moghtadaei… - Journal of molecular and …, 2018 - Elsevier
Atrial fibrillation (AF) is prevalent in hypertension and elevated angiotensin II (Ang II);
however, the mechanisms by which Ang II leads to AF are poorly understood. Here, we …

Genetic susceptibility to atrial fibrillation is associated with atrial electrical remodeling and adverse post-ablation outcome

GR Wong, CJ Nalliah, G Lee, A Voskoboinik… - Clinical …, 2020 - jacc.org
Objectives This study sought to assess the atrial electrophysiological properties and post-
ablation outcomes in patients with atrial fibrillation (AF) with and without the rs2200733 …

Role of endo-epicardial dissociation of electrical activity and transmural conduction in the development of persistent atrial fibrillation

S Verheule, J Eckstein, D Linz, B Maesen… - Progress in biophysics …, 2014 - Elsevier
Atrial fibrillation (AF) is an arrhythmia that occurs as a result of numerous pathophysiological
processes in the atria. High rate, neurohumoral activation, aging and chronic stretch activate …

[HTML][HTML] The association between diabetes mellitus and atrial fibrillation: clinical and mechanistic insights

LJ Bohne, D Johnson, RA Rose, SB Wilton… - Frontiers in …, 2019 - frontiersin.org
A number of clinical studies have reported that diabetes mellitus (DM) is an independent risk
factor for Atrial fibrillation (AF). After adjustment for other known risk factors including age …