Periodontitis is a chronic infectious disease caused by bacterial irritation. As an essential
component of the host immunity, macrophages are highly plastic and play a crucial role in …

Background Periodontitis is characterized by progressive inflammation and alveolar bone
loss resulting in tooth loss finally. Macrophages including pro-inflammatory M1-like …

Mesenchymal stem cell (MSC)–derived exosome plays a central role in the cell-free
therapeutics involving MSCs and the contents can be customized under disease-associated …

Although mesenchymal stem cell-derived exosomes (MSC-exos) have been shown to have
therapeutic effects in experimental periodontitis, their drawbacks, such as low yield and …

Macrophage polarization plays an important role in the progression of inflammation.
Exosomes derived from stem cells are promising candidates for macrophage …

Exosomes (EXs) shed by mesenchymal stem cells (MSCs) are potent therapeutic agents
that promote wound healing and regeneration, but when used alone in vivo, their …

This study aimed to explore the effects of exosomes derived from human gingival
mesenchymal stem cells (GMSC-Exo) on the inflammatory response of periodontal ligament …

Periodontitis is the primary cause of tooth loss, but there is no effective treatment to repair
inflammatory bone loss in periodontitis. Exosomes emerge as essential paracrine factors of …

Mesenchymal stem cells (MSCs) are potential therapeutics for the treatment of periodontal
defects. It is increasingly accepted that MSCs mediate tissue repair through secretion of …

Periodontitis is caused by host immune-inflammatory response to bacterial insult. A high
proportion of pro-inflammatory macrophages to anti-inflammatory macrophages leads to the …