CD4+ T‐cell responses are important for the outcome of hepatitis C virus (HCV) infection.
However, the functional status of HCV‐specific CD4+ T cells in persistent infection is poorly …

Chronic hepatitis C is characterized by a weak or absent hepatitis C virus (HCV)-specific
CD4+ T-cell response in terms of antigen-specific proliferation or interferon gamma (IFN-γ) …

This study was performed to compare the vigor and phenotype of virus-specific CD4+ and
CD8+ T-cell responses in patients with different virologic and clinical outcomes after …

Hepatitis C virus (HCV)‐specific T cell responses are essential for HCV control, and chronic
infection is characterized by functionally altered antigen‐specific T cells. It has been …

CD8+ T lymphocyte responses are important in the clearance of viral infections. In chronic
infections they may contribute to pathogenesis. To investigate the role of CD8+ T lymphocyte …

Hepatitis C virus (HCV) infection is a major cause of liver damage, with virus-induced end-
stage disease such as liver cirrhosis and hepatocellular carcinoma resulting in a high rate of …

BACKGROUND: The outcome of acute hepatitis C is determined by early host–virus
interactions, particularly involving the antiviral T-cell response. OBJECTIVES: To identify …

Background and aims: Cellular mediated immunity (CMI) is thought to play a key role in
resolution of primary hepatitis C virus (HCV) infection. However, CD4+ and CD8+ T cell …

Recruitment of virus-specific T lymphocyte subpopulations to liver sites in chronic hepatitis C
virus (HCV) infection implies a key role for the immune response in host-virus interaction. In …

CD8+ T lymphocytes play a major role in antiviral immune defense. Their significance for
acute hepatitis C is unclear. Our aim was to correlate the CD8+ T cell response with the …