Upregulation of ghrelin expression in cachectic nude mice bearing human melanoma cells

T Hanada, K Toshinai, Y Date, N Kajimura, T Tsukada… - Metabolism, 2004 - Elsevier
Ghrelin is a gastrointestinal peptide that stimulates food intake and growth hormone (GH)
secretion. We studied the biosynthesis and secretion of ghrelin in a cancer cachexia mouse …

Anti-cachectic effect of ghrelin in nude mice bearing human melanoma cells

T Hanada, K Toshinai, N Kajimura… - Biochemical and …, 2003 - Elsevier
Ghrelin is a novel brain-gut peptide that stimulates food intake and body weight gain. We
studied the anabolic effect of ghrelin in a cancer cachexia mouse model. SEKI, a human …

Involvement of ghrelin‐growth hormone secretagogue receptor system in pathoclinical profiles of digestive system cancer

Z Wang, W Wang, W Qiu, Y Fan, J Zhao… - Acta biochimica et …, 2007 - Wiley Online Library
Ghrelin receptor has been shown to be expressed along the human gastrointestinal tract.
Recent studies showed that ghrelin and a synthetic ghrelin receptor agonist improved …

Ghrelin as a promising therapeutic option for cancer cachexia

MN Khatib, A Gaidhane, S Gaidhane… - Cellular Physiology and …, 2018 - karger.com
Cachexia is a devastating complication of cancer and an important cause of morbidity and
mortality and can have a great effect on quality of life, and sense of self-esteem …

Effects of ghrelin on anorexia in tumor-bearing mice with eicosanoid-related cachexia

W Wang, M Andersson, BM Iresjö… - International …, 2006 - spandidos-publications.com
Ghrelin is a novel brain-gut peptide that stimulates food intake and may secondarily
increase body weight via a growth hormone secretagogue receptor (GHS-R). Tumor-bearing …

Ghrelin treatment causes increased food intake and retention of lean body mass in a rat model of cancer cachexia

MD DeBoer, XX Zhu, P Levasseur, MM Meguid… - …, 2007 - academic.oup.com
Cancer cachexia is a debilitating syndrome of anorexia and loss of lean body mass that
accompanies many malignancies. Ghrelin is an orexigenic hormone with a short half-life that …

Upregulation of ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration

K Toshinai, MS Mondal, M Nakazato, Y Date… - Biochemical and …, 2001 - Elsevier
Ghrelin is a novel gut–brain peptide that binds to the growth hormone secretagogue
receptor (GHS-R), thereby functioning in the regulation of growth hormone (GH) release and …

Increased plasma ghrelin level in lung cancer cachexia

Y Shimizu, N Nagaya, T Isobe, M Imazu… - Clinical Cancer …, 2003 - AACR
Purpose: Ghrelin, a novel growth hormone-releasing peptide, has been shown to cause a
positive energy balance by stimulating food intake and inducing adiposity. We sought to …

Continuous intravenous infusion of ghrelin does not stimulate feeding in tumor-bearing rats

WT Chance, R Dayal, LA Friend, I Thomas… - Nutrition and …, 2007 - Taylor & Francis
The development of anorexia continues to be a serious treatment issue for cancer patients.
Because the orexigenic peptide, ghrelin, is active through systemic routes and activates …

Effects of high-fat feeding and fasting on ghrelin expression in the mouse stomach

SG Moesgaard, B Ahrén, RD Carr, DX Gram… - Regulatory peptides, 2004 - Elsevier
Ghrelin is a peptide identified as an endogenous ligand for the growth hormone
secretagogue receptor. Studies have shown that ghrelin stimulates growth hormone …