Stroke is an emerging major health problem often resulting in death or disability.
Hyperlipidemia, high blood pressure and diabetes are well established risk factors …

Stroke is the second leading cause of death, after ischemic heart disease, and accounts for
9% of deaths worldwide. According to the World Health Organization [WHO], 15 million …

Excessive oxygen and its chemical derivatives, namely reactive oxygen species (ROS),
produce oxidative stress that has been known to lead to cell injury in ischemic stroke. ROS …

The brain endothelium constitutes a barrier to the passive movement of substances from the
blood into the cerebral microenvironment, and disruption of this barrier after a stroke or …

Transient or permanent interruption of cerebral blood flow by occlusion of a cerebral artery
gives rise to an ischaemic stroke leading to irreversible damage or dysfunction to the cells …

Stroke is one of the leading causes of mortality and morbidity, with astronomical financial
repercussions on health systems worldwide. Ischaemic stroke accounts for approximately 80 …

Excessive production of free radicals is known to lead to cell injury in a variety of diseases,
such as cerebral ischemia. In this review, we describe some of the numerous studies that …

Oxidative stress has emerged as a key deleterious factor in brain ischemia and reperfusion.
Malfunction of the oxidative respiratory chain in mitochondria combines with the activation of …

Reactive oxygen species and oxidative state are slowly gaining acceptance in having a
physiological relevance rather than just being the culprits in pathophysiological processes …

The overproduction of reactive oxygen species (ROS) and reactive nitrogen species (RNS)
is a common underlying mechanism of many neuropathologies, as they have been shown to …