We investigated the association between the MDR1 C3435T polymorphism and P-
glycoprotein function of leukemic blasts as well as clinical outcomes in 200 patients with …

The multidrug resistance (MDR1) gene product P-glycoprotein is a membrane bound protein
that functions as an ATP-dependent efflux pump, transporting exogenous and endogenous …

Multidrug‐resistance (MDR) phenotype is a serious limitation to the effective
chemotherapeutic treatment of many cancer types, including leukemia. One of the most …

Allelic variants of the MDR-1 gene have been shown recently to influence protein
expression and P-glycoprotein (P-gp) function in healthy volunteers. Therefore, 405 acute …

Abstract Multidrug resistance‐1 (MDR‐1) gene single nucleotide polymorphisms (SNPs)
have been identified as associated with the treatment outcomes of acute myeloid leukemia …

We investigated the relation between MDR-1 gene single-nucleotide polymorphisms (SNPs)
and treatment outcome in chronic myeloid leukemia (CML) patients. Two groups of patients …

Sequence variation at the proximal MDR1 promoter of 72 patients with acute myeloid
leukemia (AML) was investigated and its association with P-glycoprotein (Pgp) expression …

Background: The frequency of the multi-drug resistance 1 (MDR1) gene C3435T
polymorphism differs in various ethnical populations such as Asian, African, and Caucasians …

Abstract The C3435T (Ile1142Ile) polymorphism of the multidrug resistance gene (MDR1)
has been implicated in leukemia risk, but the reported results are inconsistent. Here we …

The significance of genetic background in childhood acute lymphoblastic leukemia (ALL) is
not well understood. Polymorphisms of genes encoding for xenobiotics and drug …